Clinical, anatomic and haemodynamic features, and serum cardiac markers in adenosine treated and control groups
| Control group (n=16) | Adenosine treated (n=12) | p Value | ||
|---|---|---|---|---|
| CCS, Canadian Cardiovascular Society; CK-MB, MB isoenzyme of creatine kinase; LAD, left anterior descending coronary artery; LCx, left circumflex coronary artery; PTCA, percutaneous transluminal coronary angioplasty; RCA, right coronary artery. | ||||
| Clinical features | ||||
| Age (years) | 66 (11) | 59 (9) | ||
| Sex (male/female) | 10/6 | 12/0 | ||
| Anginal syndrome on admission (n) | ||||
| CSS class 1–2 | 11 | 5 | ||
| CSS class 3–4 | 5 | 7 | ||
| Antianginal medications (n) | ||||
| β Blocking agents | 11 | 9 | ||
| Calcium channel blocking agents | 7 | 5 | ||
| Long acting nitrates | 7 | 4 | ||
| Anatomic and haemodynamic features | ||||
| Vessel undergoing PTCA (n) | ||||
| LAD | 5 | 8 | NS | |
| LCx | 6 | 3 | ||
| RCA | 5 | 1 | ||
| Maximal balloon diameter (mm) | 3.0 (0.3) | 3.0 (0.5) | NS | |
| Maximal balloon pressure (atm) | 9.7 (3.8) | 8.1 (3.1) | NS | |
| Stent implantation (n) | 8 | 5 | NS | |
| Systolic blood pressure (mm Hg) | ||||
| Before study drug infusion | 151 (36) | 128 (18) | NS | |
| After study drug infusion | 154 (40) | 132 (22) | NS | |
| Diastolic blood pressure (mm Hg) | ||||
| Before study drug infusion | 76 (12) | 77 (9) | NS | |
| After study drug infusion | 78 (13) | 77 (9) | NS | |
| Heart rate (beats/min) | ||||
| Before study drug infusion | 71 (14) | 70 (9) | NS | |
| After study drug infusion | 71 (12) | 74 (9) | NS | |
| Chest pain score | ||||
| During study drug infusion | 3 (10) | 50 (46) | <0.001 | |
| During balloon inflation | 75 (59) | 82 (53) | NS | |
| ST segment shift (mm) | 12.4 (11.1) | 6.1 (5.5) | 0.085 | |
| Serum cardiac markers | ||||
| Before PTCA | ||||
| CK-MB (μg/l) | 2.04 (1.05) | 2.08 (1.29) | NS | |
| Troponin I (μg/l) | 0.23 (0.50) | 0.86 (2.05) | NS | |
| 24 hours after PTCA | ||||
| CK-MB (μg/l) | 9.41 (9.86) | 3.23 (2.02) | 0.043 | |
| Troponin I (μg/l) | 3.09 (4.92) | 1.94 (2.48) | NS | |
| Difference between before and 24 hours after PTCA | ||||
| CK-MB (μg/l) | 7.36 (10.12) | 1.15 (1.90) | 0.047 | |
| Troponin I (μg/l) | 2.85 (5.00) | 1.09 (2.69) | NS | |