Causes of mitral regurgitation
| Condition | Example | Pathology |
|---|---|---|
| Primary valve | Mitral valve prolapse | Myxomatous degeneration |
| Redundant leaflet tissue | ||
| Ruptured chordae | ||
| Rheumatic heart disease | Leaflet thickening and restriction | |
| Commissural fusion | ||
| Endocarditis | Leaflet destruction | |
| Papillary muscle rupture | Myocardial infarction | |
| Congenital | Cleft mitral valve | |
| Double orifice mitral valve | ||
| Miscellaneous | Drugs (e.g. fenfluramine) | |
| Functional mitral | Mitral annular dilatation | Dilated cardiomyopathy |
| Left ventricular wall motion abnormality | Myocardial ischaemia/infarction | |