Table 1

Alteplase: structure of the molecule and function of its components

ComponentFunction
Reteplase, tenecteplase, and lanoteplase are derivatives of alteplase, components of which have been deleted or changed.
PAI-1, plasminogen activator inhibitor type 1.
Fibronectin fingerBinding to fibrin
Epidermal growth factor domainElimination by hepatocytes
Kringle 1Elimination by liver endothelial cells
Kringle 2Stimulation of protease by fibrin
Protease domainSplitting of plasminogen
Inhibition by PAI-1
Carbohydrate side chainElimination from plasma