Alteplase: structure of the molecule and function of its components
| Component | Function |
|---|---|
| Reteplase, tenecteplase, and lanoteplase are derivatives of alteplase, components of which have been deleted or changed. | |
| PAI-1, plasminogen activator inhibitor type 1. | |
| Fibronectin finger | Binding to fibrin |
| Epidermal growth factor domain | Elimination by hepatocytes |
| Kringle 1 | Elimination by liver endothelial cells |
| Kringle 2 | Stimulation of protease by fibrin |
| Protease domain | Splitting of plasminogen |
| Inhibition by PAI-1 | |
| Carbohydrate side chain | Elimination from plasma |