Effect on sensitivity and specificity of reducing the cut off value for troponin T
| Cut off point | ||||||
|---|---|---|---|---|---|---|
| Time window (hours) | 0.01μg/l | 0.03 μg/l | 0.04 μg/l | 0.05 μg/l | 0.06 μg/l | 0.1 μg/l |
| CI, confidence interval. | ||||||
| Sensitivity (CI) | ||||||
| 0 | 82.4 (74.8 to 88.6) | 69.5 (60.7 to 77.2) | 67.9 (59.4 to 76.0) | 63.4 (54.5 to 71.5) | 60.3 (51.3 to 68.9) | 53.4 (44.4 to 62.3) |
| >0 to <2 | 99.0 (96.3 to 99.9) | 77.5 (71.0 to 83.1) | 73.8 (67.0 to 79.9) | 69.6 (62.5 to 76.0) | 67.5 (60.3 to 74.2) | 60.7 (53.6 to 67.5) |
| 2 to <4 | 93.7 (85.8 to 97.9) | 83.5 (73.6 to 90.9) | 83.5 (73.6 to 90.9) | 82.3 (72.2 to 89.9) | 79.7 (69.1 to 88.0) | 73.4 (62.3 to 82.7) |
| 4 to <6 | 94.9 (87.4 to 98.6) | 92.3 (84.0 to 97.1) | 92.3 (84.0 to 97.1) | 91.0 (82.4 to 96.3) | 88.5 (79.2 to 94.6) | 85.9 (76.2 to 92.7) |
| 6 to <12 | 97.6 (94.5 to 99.2) | 95.7 (92.0 to 98.0) | 93.8 (89.7 to 96.7) | 93.8 (89.7 to 96.7) | 92.9 (88.5 to 95.9) | 92.4 (87.9 to 95.6) |
| ≥12 | 99.0 (98.0 to 99.6) | 96.0 (94.3 to 97.3) | 95.0 (93.1 to 96.5) | 94.9 (93.0 to 96.4) | 94.2 (92.2 to 95.8) | 90.7 (88.4 to 92.7) |
| Specificity (CI) | ||||||
| 0 | 60.0 (32.3 to 83.7) | 73.3 (44.9 to 92.2) | 73.3 (44.9 to 92.2) | 73.3 (44.9 to 92.2) | 73.3 (44.9 to 92.2) | 80.0 (51.9 to 95.7) |
| >0 to <2 | 51.6 (43.5 to 59.6) | 77.4 (70.0 to 83.7) | 80.0 (72.7 to 86.1) | 80.6 (73.5 to 86.5) | 82.6 (75.8 to 88.4) | 87.1 (80.7 to 92.0) |
| 2 to <4 | 35.9 (21.1 to 52.8) | 71.8 (55.4 to 85.0) | 74.4 (58.0 to 87.0) | 76.9 (60.7 to 88.9) | 76.9 (60.7 to 88.9) | 89.7 (75.8 to 97.1) |
| 4 to <6 | 43.8 (19.8 to 70.1) | 68.8 (41.3 to 89.0) | 81.3 (54.4 to 96.0) | 81.3 (54.4 to 96.0) | 81.3 (54.4 to 96.0) | 81.3 (54.4 to 96.0) |
| 6 to <12 | 31.0 (19.5 to 44.5) | 56.9 (43.3 to 69.8) | 62.1 (48.3 to 74.6) | 63.8 (49.9 to 75.9) | 67.2 (53.7 to 79.0) | 74.1 (61.1 to 84.7) |
| ≥12 | 38.6 (32.4 to 45.1) | 56.8 (50.1 to 63.2) | 58.9 (52.5 to 65.1) | 60.6 (54.2 to 66.7) | 63.1 (56.6 to 69.2) | 71.4 (65.2 to 77.0) |