Table 3

Pathological/clinical sequelae of brachytherapy/drug eluting stents

ResponseManifested byClinical sequelae
Injury without treatment (geographical miss)Acceleration of neointimal thickening at some doses or with chronic treatmentEdge restenosis In-stent stenosis
Failure of healingLack of endothelialisationLate thrombosis
Fibrin deposition/intraintimal haemorrhageLate thrombosis
Intimal inflammation? Negative remodelling
? In-stent stenosis
Adventitial inflammation? Negative remodelling
? In-stent stenosis
Failure of medial dissections to healLate thrombosis
Vascular smooth muscle cell death? Negative remodelling