Post-CABG adverse event incidence and mortality
| In-hospital adverse event incidence | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| MI | Non-fatal MI | Stroke | Non-fatal stroke | GI bleeding | Renal failure | Mortality | 30 Day mortality | ||
| * p<0.05; ** p<0.01. | |||||||||
| EF, ejection fraction; GI, gastrointestinal; NA, not available; RCT, randomised controlled trial. | |||||||||
| All CABG | Mean % (SE) | 3.89 (0.66) | 2.44 (0.28) | 2.24 (0.27) | 1.32 (0.15) | 1.46 (0.29) | 0.79 (0.15) | 1.65 (0.14) | 2.06 (0.16) |
| Median % | 2.94 | 2.44 | 1.8 | 1.29 | 1.23 | 0.67 | 1.54 | 1.99 | |
| n (k) | 69 487 (52) | 11 973 (52) | 26 750 (21) | 31 132 (52) | 12 897 (8) | 22 798 (23) | 75 933 (105) | 81 136 (70) | |
| North America | Mean % (SE) | 3.56 (0.59) | 2.82 (0.58) | 2.29 (0.39) | 1.25 (0.19) | 1.11 (0.14) | 0.88 (0.16) | 1.96 (0.20) | 2.00 (0.19) |
| Median % | 3.30 | 2.83 | 1.71 | 1.06 | 1.01 | 0.86 | 2.00 | 1.98 | |
| n (k) | 49 969 (32) | 2 454 (18) | 13 777 (12) | 25 555 (28) | 7 332 (3) | 21 410 (14) | 59 014 (49) | 47 158 (39) | |
| Europe | Mean % (SE) | 2.59 (0.33) | 2.55 (0.36) | 2.42 (1.18) | 1.30 (0.27) | 1.33 (0.91) | 0.99 (0.74) | 1.30 (0.22) | 2.21 (0.40) |
| Median % | 2.53 | 2.52 | 1.66 | 0.67 | 1.66 | 0.49 | 1.00 | 2.08 | |
| n (k) | 13 418 (15) | 8 389 (24) | 6 515 (4) | 4 256 (13) | 220 (2) | 625 (5) | 12 893 (33) | 21 156 (21) | |
| Multinational/ other | Mean % (SE) | 9.81 (5.54) | 1.94 (0.51) | 2.43 (0.22) | 1.27 (0.31) | 1.93 (0.62) | 0.06 (0.16) | 1.38 (0.33) | 1.72 (0.38) |
| Median % | 3.92 | 1.66 | 2.18 | 1.96 | 1.32 | 0.00 | 1.52 | 1.61 | |
| n (k) | 6 100 (5) | 1 130 (10) | 6 458 (5) | 1 321 (11) | 5 345 (3) | 763 (4) | 4 026 (23) | 13 240 (10) | |
| Elective CABG | Mean % (SE) | 2.84 (0.81) | 2.32 (0.40) | 2.35 (0.60) | 1.01 (0.21) | 1.18 (0.48) | 0.45 (0.18) | 1.48 (0.19)* | 1.50 (0.29)* |
| Median % | 2.17 | 2.00 | 1.59 | 0.64 | 1.23 | 0.22 | 1.00 | 1.23 | |
| n (k) | 3 313 (17) | 3371 (32) | 1 680 (7) | 9 170 (24) | 510 (2) | 1 333 (6) | 7 912 (47) | 7 764 (21) | |
| Mixed CABG | Mean % (SE) | 4.32 (0.89) | 2.64 (0.36) | 2.21 (0.31) | 1.51 (0.20) | 1.50 (0.35) | 0.89 (0.18) | 1.81 (0.18)* | 2.23 (0.19)* |
| Median % | 3.22 | 2.59 | 1.86 | 1.56 | 1.24 | 0.89 | 1.89 | 2.07 | |
| n (k) | 66 174 (35) | 8 602 (20) | 25 070 (14) | 21 962 (28) | 12 387 (6) | 21 465 (17) | 68 021 (58) | 73 372 (49) | |
| RCTs | Mean % (SE) | 6.26 (1.66)* | 2.64 (0.42) | 2.73 (0.98) | 1.00 (0.16)** | 1.23 (0.41) | 0.39 (0.23)* | 1.51 (0.21)* | 1.57 (0.28) |
| Median % | 4.21 | 2.94 | 1.86 | 1.78 | 1.23 | 0.05 | 0.98 | 1.69 | |
| n (k) | 3 449 (22) | 2 604 (34) | 1 111 (5) | 3 790 (19) | 730 (4) | 2 189 (10) | 4 949 (48) | 4 913 (23) | |
| Cohort studies | Mean % (SE) | 2.70 (0.22)* | 2.21 (0.38) | 2.15 (0.27) | 1.52 (0.18)** | 1.53 (0.40) | 0.98 (0.14)* | 1.80 (0.18)* | 2.21 (0.19) |
| Median % | 2.51 | 1.75 | 1.67 | 0.61 | 1.24 | 0.89 | 1.83 | 2.03 | |
| n (k) | 66 038 (30) | 9 369 (18) | 25 639 (16) | 27 342 (33) | 12 167 (4) | 20 609 (13) | 70 984 (57) | 76 223 (47) | |
| Single centre | Mean % (SE) | 2.77 (0.26)** | 2.34 (0.28) | 2.17 (0.37) | 1.29 (0.16) | 1.06 (0.23) | 0.97 (0.19) | 1.47 (0.15)* | 1.87 (0.16)* |
| Median % | 2.55 | 2.37 | 1.60 | 1.40 | 1.16 | 0.84 | 1.30 | 1.83 | |
| n (k) | 48 655 (40) | 11 742 (49) | 11 728 (16) | 26 977 (47) | 1 977 (4) | 6 472 (15) | 45 572 (93) | 54 218 (54) | |
| Multicentre | Mean % (SE) | 7.87 (2.66)** | 6.10 (3.50) | 2.43 (0.30) | 1.43 (0.41) | 1.60 (0.40) | 0.62 (0.22) | 2.52 (0.26)* | 2.68 (0.38)* |
| Median % | 4.04 | 6.45 | 2.59 | 1.18 | 1.31 | 0.51 | 2.63 | 2.65 | |
| n (k) | 20 832 (12) | 231 (3) | 15 022 (5) | 4 155 (5) | 10 920 (4) | 16 326 (8) | 30 361(12) | 26 918 (16) | |
| Mean EF ⩽50% | Mean % (SE) | 2.79 (0.92) | 1.82 (0.58) | 3.81 (3.02) | 0.82 (0.48) | 1.47 (0.29) | 1.09 (0.41) | 1.45 (0.38) | 1.56 (0.42) |
| Median % | 2.20 | 1.82 | 4.03 | 0.00 | 1.42 | 0.89 | 2.00 | 1.92 | |
| n (k) | 4 722 (8) | 698 (5) | 256 (2) | 2 824 (7) | 1 697 (1) | 2 758 (5) | 7 622 (15) | 5 338 (9) | |
| Mean EF >50% | Mean % (SE) | 5.99 (1.85) | 2.37 (0.46) | 1.69 (0.26) | 1.21 (0.24) | 1.02 (0.24) | 0.48 (0.17) | 1.68 (0.25) | 1.61 (0.35) |
| Median % | 3.07 | 2.41 | 1.67 | 1.18 | 1.16 | 0.49 | 1.51 | 1.23 | |
| n (k) | 22 213 (18) | 8 100 (18) | 10 186 (9) | 7 973 (15) | 1 757 (2) | 6 567 (7) | 29 121 (40) | 8 535 (17) | |
| Mean age ⩽60 years | Mean % (SE) | 3.19 (0.94) | 2.49 (0.54) | 2.75 (0.82) | 1.41 (0.42) | NA | 0.00 (2.80) | 1.21 (0.27) | 1.15 (0.44)** |
| Median % | 2.37 | 2.68 | 2.33 | 0.80 | NA | 0.00 | 1.00 | 0.78 | |
| n (k) | 4 303 (12) | 2 540 (13) | 1 613 (5) | 1 273 (6) | NA | 25 (1) | 5 885 (25) | 3 260 (12) | |
| Mean age >60 years | Mean % (SE) | 4.14 (0.84) | 2.44 (0.36) | 1.94 (0.23) | 1.28 (0.16) | 1.46 (0.29) | 0.75 (0.16) | 1.77 (0.16) | 2.26 (0.17)** |
| Median % | 3.18 | 2.51 | 1.67 | 1.45 | 1.23 | 0.6 | 1.59 | 2.07 | |
| n (k) | 63 035 (39) | 9 219 (37) | 24 681 (15) | 26 524 (44) | 12 897 (8) | 13 926 (20) | 45 921 (76) | 74 288 (54) | |
| No prior CABG | Mean % (SE) | 2.73 (0.72) | 1.99 (0.46) | 1.82 (0.40) | 0.99 (0.31) | 2.63 (1.84) | 1.23 (1.10) | 1.18 (0.28) | 1.66 (0.35) |
| Median % | 3.33 | 1.83 | 1.27 | 0.66 | 2.63 | 1.00 | 1.00 | 1.81 | |
| n (k) | 2 606 (11) | 2 115 (18) | 1 097 (4) | 3 240 (10) | 76 (1) | 270 (4) | 27 625 (25) | 8 390 (14) | |
| Some patients with prior CABG | Mean % (SE) | 6.47 (1.83) | 2.57 (0.88) | 2.19 (0.34) | 1.80 (0.15) | 1.53 (0.40) | 0.86 (0.22) | 1.92 (0.25) | 2.27 (0.23) |
| Median % | 3.32 | 1.86 | 1.8 | 1.74 | 1.24 | 0.9 | 2.01 | 2.52 | |
| n (k) | 45 306 (18) | 6 986 (6) | 19 252 (12) | 17 619 (15) | 12 167 (4) | 16 263 (9) | 32 177 (30) | 48 599 (28) | |