Drugs with potential cardiotoxicity used in HIV
| Drug | Use in HIV | Cardiotoxicity | |
|---|---|---|---|
| Nucleoside transcriptase inhibitors | HIV disease | Cardiomyopathy | |
| Non-nucleoside transcriptase inhibitors | HIV disease | Increased coronary vascular risk | |
| Protease inhibitors | HIV disease | Increased coronary vascular risk | |
| Anti-infective drugs | Opportunistic infections | ||
| Erythromycin | Prolonged QT interval | ||
| Trimethoprim/sulfamethoxazole | Prolonged QT interval | ||
| Clarithromycin | Prolonged QT interval | ||
| Pentamidine | Prolonged QT interval | ||
| Ventricular arrhythmias | |||
| Orthostatic hypotension | |||
| Pyrimethamine | Prolonged QT interval | ||
| Fluoroquinolones | Prolonged QT interval | ||
| Amphotericin B | Prolonged QT interval | ||
| Hypokalaemia | |||
| Bradycardia | |||
| Hypertension | |||
| Azole antifungals | Prolonged QT interval | ||
| Ganciclovir | Ventricular arrhythmias | ||
| Foscarnet | Cardiomyopathy | ||
| Psychotropic drugs | Psychotic disorders, depression | ||
| Tricyclic antidepressants | Prolonged QT interval | ||
| Phenothiazines | Prolonged QT interval | ||
| Antihistamines | Allergic reactions | ||
| Astemizole | Prolonged QT interval | ||
| Terfenadine | Prolonged QT interval | ||
| Chemotherapy regimens | HIV related neoplasms | ||
| Anthracyclines | Cardiomyopathy (acute/chronic) | ||
| Ventricular arrhythmias | |||
| Heart block | |||
| Vincristine | Hypertension | ||
| Coronary heart disease | |||
| Interferon α | Kaposi’s sarcoma, | Cardiomyopathy | |
| Hepatitis C infection | Coronary heart disease | ||
| Interleukin-2 | HIV disease | Cardiomyopathy | |
| Coronary heart disease | |||
| Erythropoeitin α | Chronic anaemia | Hypertension | |
| Cocaine | Recreational | Hypertension | |
| Coronary heart disease (dissection) | |||
| Cardiomyopathy | |||
| Myocarditis | |||
| Anabolic steroids | Weight gain/recreational | Coronary heart disease | |