Table 3

Drugs with potential cardiotoxicity used in HIV

DrugUse in HIVCardiotoxicity
Nucleoside transcriptase inhibitorsHIV diseaseCardiomyopathy
Non-nucleoside transcriptase inhibitorsHIV diseaseIncreased coronary vascular risk
Protease inhibitorsHIV diseaseIncreased coronary vascular risk
Anti-infective drugsOpportunistic infections
ErythromycinProlonged QT interval
Trimethoprim/sulfamethoxazoleProlonged QT interval
ClarithromycinProlonged QT interval
PentamidineProlonged QT interval
Ventricular arrhythmias
Orthostatic hypotension
PyrimethamineProlonged QT interval
FluoroquinolonesProlonged QT interval
Amphotericin BProlonged QT interval
Hypokalaemia
Bradycardia
Hypertension
Azole antifungalsProlonged QT interval
GanciclovirVentricular arrhythmias
FoscarnetCardiomyopathy
Psychotropic drugsPsychotic disorders, depression
Tricyclic antidepressantsProlonged QT interval
PhenothiazinesProlonged QT interval
AntihistaminesAllergic reactions
AstemizoleProlonged QT interval
TerfenadineProlonged QT interval
Chemotherapy regimensHIV related neoplasms
AnthracyclinesCardiomyopathy (acute/chronic)
Ventricular arrhythmias
Heart block
VincristineHypertension
Coronary heart disease
Interferon αKaposi’s sarcoma,Cardiomyopathy
Hepatitis C infectionCoronary heart disease
Interleukin-2HIV diseaseCardiomyopathy
Coronary heart disease
Erythropoeitin αChronic anaemiaHypertension
CocaineRecreationalHypertension
Coronary heart disease (dissection)
Cardiomyopathy
Myocarditis
Anabolic steroidsWeight gain/recreationalCoronary heart disease