Drugs with potential cardiotoxicity used in HIV
Drug | Use in HIV | Cardiotoxicity | |
---|---|---|---|
Nucleoside transcriptase inhibitors | HIV disease | Cardiomyopathy | |
Non-nucleoside transcriptase inhibitors | HIV disease | Increased coronary vascular risk | |
Protease inhibitors | HIV disease | Increased coronary vascular risk | |
Anti-infective drugs | Opportunistic infections | ||
Erythromycin | Prolonged QT interval | ||
Trimethoprim/sulfamethoxazole | Prolonged QT interval | ||
Clarithromycin | Prolonged QT interval | ||
Pentamidine | Prolonged QT interval | ||
Ventricular arrhythmias | |||
Orthostatic hypotension | |||
Pyrimethamine | Prolonged QT interval | ||
Fluoroquinolones | Prolonged QT interval | ||
Amphotericin B | Prolonged QT interval | ||
Hypokalaemia | |||
Bradycardia | |||
Hypertension | |||
Azole antifungals | Prolonged QT interval | ||
Ganciclovir | Ventricular arrhythmias | ||
Foscarnet | Cardiomyopathy | ||
Psychotropic drugs | Psychotic disorders, depression | ||
Tricyclic antidepressants | Prolonged QT interval | ||
Phenothiazines | Prolonged QT interval | ||
Antihistamines | Allergic reactions | ||
Astemizole | Prolonged QT interval | ||
Terfenadine | Prolonged QT interval | ||
Chemotherapy regimens | HIV related neoplasms | ||
Anthracyclines | Cardiomyopathy (acute/chronic) | ||
Ventricular arrhythmias | |||
Heart block | |||
Vincristine | Hypertension | ||
Coronary heart disease | |||
Interferon α | Kaposi’s sarcoma, | Cardiomyopathy | |
Hepatitis C infection | Coronary heart disease | ||
Interleukin-2 | HIV disease | Cardiomyopathy | |
Coronary heart disease | |||
Erythropoeitin α | Chronic anaemia | Hypertension | |
Cocaine | Recreational | Hypertension | |
Coronary heart disease (dissection) | |||
Cardiomyopathy | |||
Myocarditis | |||
Anabolic steroids | Weight gain/recreational | Coronary heart disease |