Table 3

Comparison of cohort studies with data on differential transmission of CHD to the male offspring

Study cohort	N* (cases)	Age (years)	Follow up (years)	Exposure	Outcome	Confounders	Relative risk† (95% CI)
*N represents the total number of male participants in the study with the actual number of cases occurring during the follow period shown within parentheses.
†Adjusted for age and all the other confounders shown in the adjacent column, and compared with the baseline of neither parent with CHD.
‡Relative risk (unadjusted) calculated from raw data in the article.
M, maternal; P paternal.
US male health professionals¹³	45317 (230)	40–75	2	Non-fatal and fatal CHD	Non-fatal and fatal CHD	Smoking, self reported hypercholesterolaemia and hypertension, alcohol, profession, dietary history	P: 1.7 (1.2 to 2.3) M: 2.2 (1.2 to 3.8)
Framingham¹⁸	1713 (565)	28–62	28	Fatal CHD	Non-fatal and fatal CHD	Smoking, serum cholesterol, BP, obesity, glucose intolerance, left ventricular hypertrophy	P: 1.2 (1 to 1.5) M: 1.4 (1.1 to 1.8)
Tecumseh community¹⁵	1402 (57)	40–59	4	Fatal CHD	Non-fatal and fatal CHD	Serum cholesterol, BP, blood glucose	P: 3.9 (1.9 to 8.4)‡ M: 3.8 (1.9 to 7.9)
British regional heart¹⁷	7735 (336)	40–59	6	Fatal CHD	Non-fatal and fatal CHD	Smoking, serum cholesterol, BP	P: 2.1 (1.4 to 3.3) M: 1.3 (0.9 to 1.9)
Paris prospective¹⁴	7484 (258)	43–54	7	Non-fatal and fatal CHD	Non-fatal and fatal CHD	Smoking, serum cholesterol, BP, diabetes	P: 1.5 (1.0 to 2.1) M: 1.0 (0.6 to 1.7)
Finland¹⁶	7609 (768)	30–59	12	Non-fatal and fatal CHD	Non-fatal and fatal CHD	Smoking, serum cholesterol, BP, diabetes, obesity, social class	P: 1.7 (1.4 to 2.0) M: 1.3 (1.0 to 1.8)
US physicians²¹	20515 (653)	40–84	13	Non-fatal and fatal CHD	Non-fatal and fatal CHD	Self reported smoking, alcohol, exercise, obesity	P: 1.6 (1.3 to 1.9) M: 2.1 (1.6 to 2.8)
Goteborg primary prevention²²	6242 (1 346)	51–59	21	Non-fatal and fatal CHD	Non-fatal and fatal CHD	Smoking, BP, obesity, physical activity, serum cholesterol, diabetes, social class	P: 1.5 (1.3 to 1.7) M: 1.5 (1.3 to 1.8)
Glasgow students	8402 (373)	16–30	43	Non-fatal and fatal CHD	Fatal CHD	Smoking, BP, obesity, father’s social class, height	P: 1.5 (1.1 to 2.2) M: 1.2 (0.6 to 2.3)