Table 1

Baseline characteristics and clinical presentations of the study population

ACSSTEMINSTEMI/UA
Renal functionSevere dysfunction (n=786)Moderate dysfunction (n=3397)Normal/ minimally impaired (n=7591)Severe dysfunction (n=301)Moderate dysfunction (n=1347)Normal/ minimally impaired (n=3068)Severe dysfunction (n=485)Moderate dysfunction (n=2050)Normal/ minimally impaired (n=4523)
Severe renal dysfunction: creatinine clearance (CC) <30 ml/min; moderate renal dysfunction: CC 30–60 ml/min; normal/minimally impaired renal function: CC >60 ml/min.
*p < 0.05 across all categories of renal function within acute coronary syndromes (ACS), ST segment elevation myocardial infarction (STEMI), or non-ST segment elevation myocardial infarction/unstable angina (NSTEMI/UA) subgroups;
**p<0.0001 across all categories of renal function within ACS, STEMI, or NSTEMI/UA subgroups;
†p<0.0001 across all age groups and categories of renal function within ACS, STEMI, and NSTEMI/UA subgroups;
‡p<0.0001 across all Killip classes and categories of renal function within ACS, STEMI, and NSTEMI/UA subgroups.
CABG, coronary artery bypass grafting; PCI, percutaneous coronary intervention; TIA, transient ischaemic attack.
Demographic characteristics
    Age (median, years)79.074.959.7**80.174.958.6**78.375.060.5**
    Age ⩾ 65 years (%)85.685.333.9†87.085.230.5†84.785.436.2†
    Male sex (%)40.851.378.2**36.554.783.1**43.549.074.9**
Medical history (%)
    Diabetes32.026.821.8**28.527.119.8**34.226.723.2**
    Myocardial infarction40.435.628.5**37.029.420.7**42.439.633.8*
    Heart failure28.816.35.7**26.415.24.6**30.417.06.4**
    Hypertension75.865.754.4**70.062.347.3**79.368.059.2**
    Peripheral vascular disease22.814.18.4**18.713.16.6**25.414.79.6**
    Atrial fibrillation14.612.55.1**14.411.63.3**14.613.16.4**
    TIA/stroke15.911.15.6**16.110.54.4**15.711.46.4**
    Current smoker9.013.934.2**11.016.844.1**7.812.127.5**
    CABG14.415.411.6**9.410.56.6**17.418.615.0*
    PCI12.614.415.7*9.48.89.114.518.020.1*
Presentation
    Time from symptom onset to admission (median, min)210180165**196165140**215200188
    ECG changes (%)76.272.070.7*82.186.094.7**72.662.854.5**
    Killip class‡ (%)
        I64.375.089.260.271.186.966.877.690.8
        II25.019.99.126.122.110.824.318.48.0
        III10.85.11.713.76.82.38.94.01.3