Traditional cardiovascular risk factors in patients with severe aortic stenosis and controls with normal aortic valves (pair matched for age, sex, and the presence of stenotic coronary artery disease on angiography)
| Severe aortic stenosis without CAD | Normal aortic valve without CAD | p Value | Odds ratio (95% CI) | |
|---|---|---|---|---|
| n | 246 | 246 | ||
| Male sex* | 98 (40%) | 98 (40%) | ||
| Age (years)* (mean (SD)) | 69 (8) | 69 (8) | ||
| Cardiovascular risk factors | ||||
| Hypertension | 136 (55%) | 154 (63%) | 0.119 | 0.74 (0.52 to 1.06) |
| Hypercholesterolaemia | 94 (40%) | 142 (58%) | 0.001 | 0.45 (0.32 to 0.65) |
| Smoking | 80 (33%) | 61 (25%) | 0.072 | 1.46 (0.98 to 2.16) |
| FH of CAD | 52 (21%) | 60 (24%) | 0.452 | 0.83 (0.55 to 1.27) |
| Diabetes mellitus | 39 (16%) | 39 (16%) | 1.000 | 1.00 (0.62 to 1.62) |
| Severe aortic stenosis with CAD | Normal aortic valve with CAD | |||
|---|---|---|---|---|
| Values are n (%) unless stated. | ||||
| *Matched. | ||||
| CAD, coronary artery disease; CI, confidence interval; FH, family history. | ||||
| n | 277 | 277 | ||
| Male sex* | 189 (68%) | 189 (68*) | ||
| Age (years)* (mean (SD)) | 70 (7) | 70 (7) | ||
| Cardiovascular risk factors | ||||
| Hypertension | 172 (62%) | 174 (63%) | 0.930 | 0.97 (0.69 to 1.36) |
| Hypercholesterolaemia | 164 (59%) | 167 (60%) | 0.862 | 0.96 (0.68 to 1.34) |
| Smoking | 133 (48%) | 117 (42%) | 0.200 | 1.26 (0.90 to 1.76) |
| FH of CAD | 92 (33%) | 65 (24%) | 0.014 | 1.62 (1.12 to 2.36) |
| Diabetes mellitus | 67 (24%) | 56 (20%) | 0.307 | 1.26 (0.84 to 1.88) |