Group means
| Group mean (SD) | Significance of F | |||||||
|---|---|---|---|---|---|---|---|---|
| Test | Group | Preoperative | Discharge | Three months | Number | Drug | Time | Interaction |
| AMIPB, test A from the adult memory and information processing battery; AVLT, delayed recall on the auditory verbal learning test; TMTB, trail-making test B ( following natural logarithmic conversion); VFT, verbal fluency test. | ||||||||
| For AVLT, AMIPB, and VFT a higher score represents improved performance. TMTB is a timed test so that a higher score represents impaired performance. | ||||||||
| AVLT | Placebo | 14.4 (5.4) | 13.0 (5.1) | 14.5 (5.7) | 46 | 0.30 | 0.000 | 0.29 |
| 10 mg lexipafant | 14.4 (5.4) | 11.8 (5.9) | 13.6 (6.1) | 45 | ||||
| 100 mg lexipafant | 14.0 (4.7) | 10.9 (4.9) | 12.3 (4.2) | 40 | ||||
| AMIPB | Placebo | 61.3 (13.9) | 55.4 (12.6) | 62.3 (13.0) | 48 | 0.21 | 0.000 | 0.18 |
| 10 mg lexipafant | 57.4 (14.7) | 49.9 (14.9) | 59.8 (15.7) | 45 | ||||
| 100 mg lexipafant | 57.0 (10.3) | 49.5 (13.6) | 59.4 (11.8) | 41 | ||||
| TMTB (ln) | Placebo | 4.52 (0.44) | 4.62 (0.46) | 4.35 (0.32) | 48 | 0.45 | 0.000 | 0.50 |
| 10 mg lexipafant | 4.53 (0.45) | 4.69 (0.56) | 4.42 (0.53) | 45 | ||||
| 100 mg lexipafant | 4.58 (0.41) | 4.80 (0.63) | 4.45 (0.45) | 42 | ||||
| VFT | Placebo | 41.0 (13.5) | 40.2 (11.9) | 41.9 (13.5) | 47 | 0.05 | 0.001 | 0.50 |
| 10 mg lexipafant | 39.4 (12.5) | 38.9 (12.2) | 42.7 (12.1) | 43 | ||||
| 100 mg lexipafant | 35.6 (12.0) | 34.0 (11.6) | 36.3 (10.9) | 39 | ||||