Cardiopulmonary exercise test results after administration of placebo and diamorphine
| Placebo | Diamorphine | p Value | |
|---|---|---|---|
| All results expressed as mean (SEM). | |||
| *p<0.05 placebo v diamorphine; | |||
| **p<0.01 placebo v diamorphine. | |||
| AT, anaerobic threshold; ETPco2, end tidal partial pressure of carbon dioxide; HR, heart rate; MAP, mean systemic arterial blood pressure; RER, respiratory exchange ratio; RR, respiratory rate; V̇o2, oxygen consumption; VE–V̇co2 slope, slope of the regression line relating minute ventilation to carbon dioxide production during exercise. | |||
| V̇o2 (ml/kg/min) | |||
| Rest | 4.24 (0.3) | 4.22 (0.23) | 0.97 |
| 3 minutes | 12.47 (0.68) | 13.15 (0.88) | 0.31 |
| 6 minutes | 14.65 (0.88) | 15.7 (1)** | 0.01 |
| Peak | 20.24 (1.49) | 21.08 (1.57)* | 0.045 |
| Tidal volume (ml) | |||
| Rest | 627 (36) | 710 (60)* | 0.04 |
| 3 minutes | 1179 (60) | 1297 (85)* | 0.03 |
| 6 minutes | 1381 (68) | 1481 (94) | 0.08 |
| Peak | 1853 (122) | 1985 (117)* | 0.02 |
| VE–V̇co2 slope | 32.75 (1.96) | 31.19 (1.71)* | 0.048 |
| Exercise duration (s) | 673 (5) | 685 (58) | 0.62 |
| Peak RER | 1.08 (0.02) | 1.10 (0.02) | 0.36 |
| AT (ml/kg/min) | 13.34 (0.85) | 14.34 (1.11) | 0.45 |
| Peak HR (beats/min) | 135 (6) | 137 (6) | 0.75 |
| Peak MAP (mm Hg) | 113 (4) | 113 (4) | 0.96 |
| ETPco2 (mm Hg) | 38.1 (1.7) | 39 (1.8) | 0.11 |
| RR (breaths/min) | 31 (2) | 29 (1) | 0.12 |