Patient characteristics
| Group A (n = 53) | Group B (n = 172) | p Value | |
|---|---|---|---|
| Data are mean (SD) or percentages. | |||
| *Significant difference. | |||
| Group A, consumption of < 50 g of alcohol a week; group B, consumption of ⩾ 50 g of alcohol a week. | |||
| ACE, angiotensin converting enzyme; AT2, angiotensin type 2; BMI, body mass index; BP, blood pressure; CABG, coronary artery bypass graft; HDL, high density lipoprotein; LDL, low density lipoprotein; LVEF, left ventricular ejection fraction; MI, myocardial infarction; PTCA, percutaneous transluminal coronary angioplasty; TSH, thyroid stimulating hormone. | |||
| Age (years) | 63.5 (10.4) | 63.0 (8.1) | 0.79 |
| Arterial hypertension (%) | 69.8 | 72.1 | 0.73 |
| Systolic BP (mm Hg) | 133 (21.7) | 134 (16.8) | 0.69 |
| Diastolic BP (mm Hg) | 80.3 (10.6) | 81.4 (9.7) | 0.50 |
| BMI | 26.1 (2.8) | 26.4 (3.2) | 0.61 |
| Diabetes (%) | 26.4 | 19.8 | 0.34 |
| Smokers (%) | 15.1 | 17.4 | 0.84 |
| Previous MI (%) | 41.5 | 33.7 | 0.33 |
| Previous PTCA (%) | 47.2 | 43.0 | 0.64 |
| Previous CABG (%) | 24.5 | 13.4 | 0.08 |
| Medication (%) | |||
| β Blocker | 86.8 | 89.0 | 0.63 |
| ACE inhibitor | 73.6 | 63.4 | 0.19 |
| AT2 receptor antagonist | 9.4 | 7.6 | 0.77 |
| Calcium antagonist | 24.5 | 18.6 | 0.33 |
| ADP receptor antagonist | 7.5 | 9.3 | 1.0 |
| Aspirin | 81.1 | 86.6 | 0.37 |
| Statins | 73.6 | 82.0 | 0.24 |
| Other lipid modifying drugs | 1.9 | 4.1 | 0.68 |
| Laboratory parameters | |||
| Creatinine (μmol/l) | 88.4 (22.1) | 88.4 (23.9) | 0.93 |
| TSH (mU/L) | 0.98 (0.61) | 1.12 (0.96) | 0.32 |
| Homocysteine (µmol/l) | 10.9 (3.06) | 11.1 (3.98) | 0.78 |
| HDL cholesterol (mmol/l) | 1.04 (0.27) | 1.15 (0.28) | 0.01* |
| LDL cholesterol (mmol/l) | 2.82 (0.97) | 2.84 (0.81) | 0.85 |
| Total cholesterol (mmol/l) | 4.50 (1.01) | 4.71 (0.94) | 0.23 |
| Triglyceride (g/l) | 1.27 (0.70) | 1.35 (0.86) | 0.54 |
| Haemoglobin A1c (%) | 5.9 (1.18) | 6.0 (0.93) | 0.69 |
| Number of diseased vessels (%) | 0.009* | ||
| 1 | 7.5 | 26.2 | |
| 2 | 24.5 | 25.6 | |
| 3 | 67.9 | 48.3 | |
| Reduced LVEF (%) | 43.4 | 26.2 | 0.025* |