Ex vivo experiments to assess irradiation dependent platelet activation
| After 20 Gy irradiation (n = 4) | After 160 Gy irradiation (n = 4) | Not radiated control samples (n = 8) | |
|---|---|---|---|
| Platelet activation tended to be higher in our in vitro experiments than in our patients. These differences may be due to the irradiation procedure in our in vitro experiments, which took about 15 minutes. The blood of our study patients, on the other hand, was fixed immediately after blood sampling to prevent any platelet activation. | |||
| GP, glycoprotein; TSP, thrombospondin. | |||
| % TSP positive platelets | 10.8 (9.9 to 12.7) | 11.0 (10.5 to 13.2) | 13.7 (10.8 to 16.3) |
| % CD 63 positive platelets | 18.1 (16.5 to 20.5) | 25.2 (21.9 to 35.0) | 23.4 (18.1 to 30.6) |
| GPIIb/IIIa on platelet surface | 414.2 (379.4 to 466.6) | 360.5 (318.2 to 407.6) | 373.5 (336.8 to 412.3) |