Diagnostic value of NT-proBNP in detecting left ventricular systolic dysfunction
| LVEF cut off | Sensitivity/specificity | PPV/NPV | AUC | NT-proBNP (pmol/l)* | Diagnoses made per 100 screened | Diagnoses missed per 100 screened | False positives per 100 screened |
|---|---|---|---|---|---|---|---|
| AUC, area under the curve; LVEF, left ventricular ejection fraction; NPV, negative predictive value; PPV, positive predictive value. | |||||||
| *NT-proBNP concentration corresponding to optimal combination of sensitivity and specificity. | |||||||
| 50% (n = 77) | 0.70/0.63 | 0.20/0.94 | 0.70 | 41.5 | 8.02 | 3.44 | 32.8 |
| 45% (n = 58) | 0.74/0.64 | 0.16/0.96 | 0.73 | 43.3 | 6.39 | 2.24 | 32.9 |
| 40% (n = 38) | 0.76/0.67 | 0.12/0.98 | 0.79 | 48.9 | 4.30 | 1.36 | 31.1 |
| 35% (n = 21) | 0.76/0.85 | 0.14/0.99 | 0.83 | 100.5 | 2.38 | 0.75 | 14.5 |