Diagnostic value of NT-proBNP in detecting systolic heart failure
| Diagnosis* | SENS/SPEC | PPV/NPV | AUC | NT-proBNP (pmol/l)† | Diagnoses made per 100 screened | Diagnoses missed per 100 screened | False positives per 100 screened | |
|---|---|---|---|---|---|---|---|---|
| *HF ⩽50/40 indicates patients with symptoms of HF and LVEF ⩽50/40%. | ||||||||
| †NT-proBNP concentration corresponding to optimal combination of sensitivity and specificity. | ||||||||
| ‡Patients with a history of ischaemic heart disease (angina or previous myocardial infarction), history of hypertension, or diabetes mellitus. | ||||||||
| All (n = 672) | HF⩽50 (n = 49) | 0.65/0.80 | 0.20/0.97 | 0.77 | 72.8 | 4.74 | 2.55 | 18.5 |
| HF⩽40 (n = 13) | 0.92/0.86 | 0.11/1.00 | 0.94 | 106.7 | 1.78 | 0.15 | 13.7 | |
| Age > 70 years (n = 294) | HF⩽50 (n = 36) | 0.64/0.74 | 0.26/0.94 | 0.74 | 106.7 | 7.84 | 4.41 | 22.8 |
| HF⩽40 (n = 11) | 0.91/0.91 | 0.29/1.00 | 0.94 | 229.0 | 3.40 | 0.34 | 8.66 | |
| High risk medical history‡ (n = 246) | HF⩽50 (n = 34) | 0.68/0.72 | 0.28/0.93 | 0.73 | 72.8 | 9.40 | 4.42 | 24.1 |
| HF⩽40 (n = 9) | 0.89/0.80 | 0.14/0.99 | 0.90 | 106.7 | 3.26 | 0.40 | 19.3 | |