Table 4

Diagnostic value of NT-proBNP in detecting systolic heart failure

Diagnosis*SENS/SPECPPV/NPVAUCNT-proBNP (pmol/l)†Diagnoses made per 100 screenedDiagnoses missed per 100 screenedFalse positives per 100 screened
*HF ⩽50/40 indicates patients with symptoms of HF and LVEF ⩽50/40%.
†NT-proBNP concentration corresponding to optimal combination of sensitivity and specificity.
‡Patients with a history of ischaemic heart disease (angina or previous myocardial infarction), history of hypertension, or diabetes mellitus.
All (n  =  672)HF⩽50 (n = 49)0.65/0.800.20/0.970.7772.84.742.5518.5
HF⩽40 (n = 13)0.92/0.860.11/1.000.94106.71.780.1513.7
Age > 70 years (n  =  294)HF⩽50 (n = 36)0.64/0.740.26/0.940.74106.77.844.4122.8
HF⩽40 (n = 11)0.91/0.910.29/1.000.94229.03.400.348.66
High risk medical history‡ (n  =  246)HF⩽50 (n = 34)0.68/0.720.28/0.930.7372.89.404.4224.1
HF⩽40 (n = 9)0.89/0.800.14/0.990.90106.73.260.4019.3