Left ventricular ejection fraction, heart rate, and blood pressure during three repetitive 90 second balloon dilatations
| Variable | Placebo (n = 14) | Pinacidil (n = 14) | Glibenclamide (n = 10) | ||
|---|---|---|---|---|---|
| Values are mean (SD). | |||||
| *p<0.05 v baseline. | |||||
| HR, heart rate; LVEF, left ventricular ejection fraction; %ΔLVEF, per cent change v baseline; MAP, mean arterial pressure; RRP, heart rate × systolic blood pressure. | |||||
| Baseline | LVEF | 0.57 (0.09) | 0.62 (0.10) | 0.58 (0.10) | NS |
| MAP (mm Hg) | 98 (12) | 96 (15) | 102 (21) | NS | |
| HR (beats/min) | 66 (14) | 71 (16) | 61 (10) | NS | |
| RRP (103 mm Hg/min) | 8.1 (2.1) | 9.2 (3.7) | 8.2 (2.6) | NS | |
| Inflation 1 | LVEF | 0.33 (0.12)* | 0.37 (0.09)* | 0.36 (0.14)* | NS |
| %ΔLVEF | 43 (18) | 41 (14) | 37 (21) | NS | |
| MAP (mm Hg) | 107 (20)* | 100 (19) | 101 (22) | NS | |
| HR (beat/min) | 70 (14) | 73 (20) | 68 (12) | NS | |
| RRP (103 mm Hg/min) | 9 (2.5) | 8.5 (3.1) | 8.3 (2.3) | NS | |
| Reperfusion 1 | LVEF | 0.60 (0.09) | 0.65 (0.11) | 0.60 (0.10) | NS |
| MAP (mm Hg) | 107 (16) | 106 (17) | 102 (19) | NS | |
| HR (beats/min) | 63 (12) | 68 (16) | 60 (9) | NS | |
| RRP (103 mm Hg/min) | 8.8 (2.9) | 9.6 (2.9) | 8.0 (2.4) | NS | |
| Inflation 2 | LVEF | 0.32 (0.11)* | 0.36 (0.10)* | 0.37 (0.13)* | NS |
| %ΔLVEF | 44 (15) | 42 (15) | 49 (36) | NS | |
| MAP (mm Hg) | 112 (21)* | 104 (23)* | 102 (20) | NS | |
| HR (beats/min) | 69 (14) | 70 (16) | 61 (12) | NS | |
| RRP (103 mm Hg/min) | 9.3 (2.9)* | 9.4 (4.0) | 7.6 (2.6) | NS | |
| Reperfusion 2 | LVEF | 0.60 (0.09) | 0.65 (0.10) | 0.60 (0.10) | NS |
| MAP (mm Hg) | 109 (18) | 106 (17) | 102 (22) | NS | |
| HR (beats/min) | 60 (10) | 67 (16) | 59 (10) | NS | |
| RRP (103 mm Hg/min) | 8.6 (2.7) | 9.5 (3) | 7.9 (2.6) | NS | |
| Inflation 3 | LVEF | 0.33 (0.12)* | 0.36 (0.10)* | 0.37 (0.12)* | NS |
| %ΔLVEF | 42 (17) | 43 (14) | 45 (34) | NS | |
| MAP (mm Hg) | 111 (23)* | 104 (19) | 106 (24) | NS | |
| HR (beats/min) | 67 (14) | 67 (16) | 62 (12) | NS | |
| RRP (103 mm Hg/min) | 9.1 (3) | 8.7 (3.0) | 8.0 (2.7) | NS | |
| Reperfusion 3 | LVEF | 0.59 (0.10) | 0.64 (0.10) | 0.60 (0.10) | NS |
| MAP (mm Hg) | 110 (16) | 105 (22) | 103 (22) | NS | |
| HR (beats/min) | 61 (10) | 63 (14) | 59 (10) | NS | |
| RRP (103 mm Hg/min) | 8.7 (2.5) | 8.8 (2.7) | 8.0 (2.9) | NS | |