Relation between the echocardiogram and the clinical status of patients with chronic Chagas disease grouped by Kuschnir classification
| Variable | Group 0 (505 patients) | Group 1 (257 patients) | Group 2 (87 patients) | Statistic |
|---|---|---|---|---|
| *Significantly different from groups 1 and 2; †significantly different from groups 0 and 2; ‡only one clinical event was considered per patient; §significantly different from groups 0 and 1, ¶significant difference between groups 0, 1, and 2. | ||||
| Age at admission (years) | 40.53 (10.9)* | 47.18 (10.26) | 49.93 (9.36) | F = 51.75 |
| p<0.0001 | ||||
| Follow up (years) | 9.64 (5.13) | 10.67 (5.53)† | 9.37 (5.49) | F = 3.72 |
| p<0.02 | ||||
| NEARD | 33/505 (6%) | 55/257 (21%) | 33/87 (38%) | χ2 = 75.27 |
| p<0.0001 | ||||
| Change in clinical group | 30/505 (6%) | 25/257 (10%) | 28/87 (32%) | χ2 = 57.95 |
| p<0.0001 | ||||
| Mortality | 0/505 (0%) | 4/257 (1%) | 12/87 (14%) | χ2 = 76.57 |
| p<0.0001 | ||||
| Clinical events‡ | 39/505 (8%) | 66/257 (26%) | 45/87 (52%) | χ2 = 115.05 |
| p<0.0001 | ||||
| RVDD (cm) | 1.80 (0.48) | 1.86 (0.56) | 2.16 (0.75)§ | F = 13.83 |
| P<0.0001 | ||||
| LVDD¶ (cm) | 4.81 (0.50) | 4.98 (0.56) | 5.94 (0.74) | F = 155.92 |
| p<0.0005 | ||||
| LVSD¶ (cm) | 2.91 (0.54) | 3.05 (0.66) | 4.30 (0.97) | F = 175,33 |
| p<0.0005 | ||||
| LASD (cm) | 3.35 (0.49) | 3.45 (0.49) | 3.99 (0.93)§ | F = 45.80 |
| p<0.0001 | ||||
| PWT (cm) | 0.89 (0.25) | 0.90 (0.16) | 0.85 (0.18) | F = 1.81 |
| p<0.16 | ||||
| SWT (cm) | 0.96 (0.22) | 1.00 (0.26) | 0.98 (0.22) | F = 2.16 |
| p<0.11 | ||||
| Radius: thickness ratio | 2.83 (0.65) | 2.80 (0.61) | 3.69 (1.11)§ | F = 53.55 |
| p<0.0001 | ||||
| E point septal separation¶ (cm) | 0.49 (0.33) | 0.70 (0.43) | 1.35 (0.64) | F = 106.77 |
| p<0.0005 | ||||
| Fractional shortening (%) | 39.36 (8.47) | 37.57 (11.30) | 26.65 (12.04)§ | F = 32.78 |
| p<0.0001 | ||||
| Systolic dysfunction | 4/505 (0.8%) | 22/257 (8%) | 42/87 (48%) | χ2 = 226.93 |
| p<0.0001 | ||||
| Segmental lesions | 66/505 (13%) | 84/257 (33%) | 61/87 (70%) | χ2 = 141.42 |
| p<0.0001 | ||||
| EF (%) | 0.69 (0.09) | 0.68 (0.11) | 0.52 (0.16)§ | χ2 = 85.12 |
| p<0.0001 | ||||