Table 1

 A summary of cost effectiveness data from five major primary percutaneous coronary intervention publications

Study nameSettingDesignInitial costs measuredFollow up costs measuredResults
Reeder et al 19945USARandomised to either t-PA or primary angioplasty; n = 99Hospital stay, all diagnostic or therapeutic proceduresCosts over 12 months including indirect costs such as lost employment daysNo significant difference in initial or follow up costs. Trend towards fewer late in-hospital procedures and shorter hospital stay in the primary angioplasty group
de Boer et al 19952NetherlandsRandomised to either streptokinase or primary angioplasty; n = 301Hospital stay, angiography, angioplasty, coronary bypass surgery, thrombolysisCosts over 12 months, additional hospital stay and cardiac procedures, cardiac medication onlyHigher in-hospital costs with primary angioplasty but no significant difference in costs at 12 months
Stone et al 19976USARandomised to either t-PA or primary PCI; n = 358Hospital charges from index admission, professional, cardiology and cardiac surgery fees2 year resource consumption was approximated by tabulating hospital readmissions and major clinical eventsTrend towards lower initial charges associated with primary PCI. Significantly lower if professional fees excluded
Suryapranata et al 20013NetherlandsRandomised to either primary stenting or balloon angioplasty; n = 227Hospital stay, all diagnostic or therapeutic proceduresCosts over 24 months. Limited to cardiac hospital admissions and cardiac outpatient visits and diagnostic testsHigher initial costs with stenting but no difference at 24 months
Le May et al 20037CanadaRandomised to either t-PA or primary stenting; n = 123Hospital stay, all diagnostic and therapeutic procedures6 month follow up, subsequent hospital stay and all diagnostic and therapeutic proceduresSignificant reduction in costs of initial hospitalisation and costs at 6 months in favour of primary stenting