Effects of intracoronary infusion of l-arginine, vitamin C, combined l-arginine and vitamin C, and nitrates on proximal and distal coronary segments
| Infusion | Group A: l-arg + vitamin C | Group B: l-arg + NS | Group C: vitamin C + NS | |||
|---|---|---|---|---|---|---|
| Diameter (mm) | Change from baseline (%) | Diameter (mm) | Change from baseline (%) | Diameter (mm) | Change from baseline (%) | |
| Values are expressed as mean (SEM). | ||||||
| *p<0.05, **p<0.01 versus baseline; †p<0.01 versus l-arg. | ||||||
| NS, normal saline. | ||||||
| Proximal segment | ||||||
| Baseline | 3.02 (0.12) | 3.06 (0.12) | 2.92 (0.12) | |||
| NS | 3.04 (0.12) | 0.64 (0.30) | 3.08 (0.11) | 0.78 (0.41) | 2.92 (0.12) | −0.17 (0.84) |
| l-arginine | 3.16 (0.13) | 4.87 (0.96)** | 3.21 (0.13) | 5.20 (1.56)** | ||
| l-arg + NS | 3.23 (0.13) | 5.36 (1.33)** | ||||
| Vitamin C + NS | 2.98 (0.11) | 1.93 (0.76)* | ||||
| l-arg + vitamin C | 3.27 (0.12) | 8.68 (1.40)** † | ||||
| Nitrates | 3.59 (0.12) | 19.61 (1.94)** † | 3.49 (0.14) | 14.20 (2.15)** † | 3.39 (0.12) | 16.12 (1.22)** † |
| Distal segment | ||||||
| Baseline | 1.66 (0.09) | 1.53 (0.08) | 1.77 (0.06) | |||
| NS | 1.66 (0.09) | −0.08 (0.48) | 1.55 (0.08) | 1.21 (0.65) | 1.77 (0.06) | 0.37 (0.90) |
| l-arg | 1.76 (0.10) | 6.33 (1.38)** | 1.59 (0.07) | 4.23 (1.37)* | ||
| l-arg + NS | 1.62 (0.08) | 5.96 (1.52)** | ||||
| Vitamin C + NS | 1.80 (0.06) | 2.09 (1.28) | ||||
| l-arg + vitamin C | 1.87 (0.10) | 13.07 (2.15)** † | ||||
| Nitrates | 2.05 (0.10) | 24.64 (1.81)** † | 1.91 (0.10) | 24.78 (3.19)** † | 2.15 (0.06) | 22.38 (1.56)** † |