Table 1

 Preconditioning: key points

RISK, reperfusion injury salvage kinase.
• Preconditioning is the mechanism by which brief periods of sublethal ischaemia can render a heart more resistant to subsequent periods of more prolonged ischaemia
• The RISK pathway is important in preconditioning
• Mitochondria are also involved in ischaemic preconditioning
• Angiotensin II blockade mimics preconditioning
• Diabetes also affects late preconditioning