Major cardiovascular events (rate per 1000 person-years) among seniors with GCA relative to patients with osteoarthritis or to unaffected controls
| Event | GCA (n = 1141) | Osteoarthritis (n = 172 953) | Unaffected controls (n = 200 000) | GCA v unaffected controls | GCA v osteoarthritis | ||
|---|---|---|---|---|---|---|---|
| Number (rate per 1000 person-years) | Crude HR (95% CI) | Adjusted HR† (95% CI) | Crude HR (95% CI) | Adjusted HR† (95% CI) | |||
| *Diagnosis of coronary artery disease (CAD), stroke, peripheral arterial disease (PAD), or aortic aneurysm or dissection. | |||||||
| †Adjusted for age, sex, hospitalisation within one year before study entry, newly diagnosed cancer, current prescription of any medication for the treatment of hyperglycaemia or hypertension, and current prescription of either a lipid lowering agent, aspirin or warfarin, oestrogen, NSAID (including cyclo-oxygenase 2 inhibitors), or prednisone, methylprednisone, azathioprine, or methotrexate. | |||||||
| CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio. | |||||||
| CVD composite* | 37 (12.1) | 3172 (7.3) | 3401 (5.3) | 2.4 (1.7 to 3.3) | 2.1 (1.5 to 3.0) | 1.6 (1.2 to 2.2) | 1.6 (1.1 to 2.2) |
| CAD | 25 (8.2) | 2350 (5.4) | 2567 (4.0) | 2.1 (1.4 to 3.2) | 1.9 (1.2 to 2.7) | 1.5 (1.0 to 2.2) | 1.4 (0.9 to 2.1) |
| Stroke | 6 (1.9) | 551 (1.3) | 600 (0.9) | 2.2 (1.0 to 4.9) | 2.1 (0.9 to 4.6) | 1.5 (0.7 to 3.4) | 1.5 (0.7 to 3.5) |
| PAD | 3 (1.0) | 128 (0.3) | 125 (0.2) | 5.2 (1.7 to 16.5) | 4.7 (1.5 to 14.9) | 3.2 (1.0 to 10.2) | 2.8 (0.9 to 8.8) |
| Aortic aneurysm or dissection | 3 (1.0) | 176 (0.4) | 187 (0.3) | 3.5 (1.1 to 11.0) | 3.2 (1.0 to 10.1) | 2.4 (0.8 to 7.4) | 2.3 (0.7 to 7.3) |