Table 3

 Case–control analysis: association between new antidepressant exposure and first MI

First prescription (days before first MI)*Cases (n = 63512)Controls (n = 378886)OR (95% CI)
*Baseline group has no prescriptions before first MI; †0 days is the day of first MI.
SSRIs
    Any SSRI
        0†13 (0.02%)16 (0%)4.96 (2.39 to 10.32)
        1–737 (0.06%)84 (0.02%)2.66 (1.81 to 3.92)
        8–1425 (0.04%)83 (0.02%)1.79 (1.15 to 2.81)
        15–2124 (0.04%)79 (0.02%)1.86 (1.18 to 2.95)
        22–2822 (0.03%)80 (0.02%)1.65 (1.03 to 2.65)
        >282428 (3.82%)10097 (2.66%)1.47 (1.41 to 1.54)
    Fluoxetine
        0†10 (0.02%)4 (0%)15.09 (4.73 to 48.11)
        1–716 (0.03%)37 (0.01%)2.59 (1.44 to 4.66)
        8–1414 (0.02%)43 (0.01%)1.89 (1.03 to 3.48)
        15–2112 (0.02%)35 (0.01%)2.08 (1.08 to 4.01)
        22–2812 (0.02%)44 (0.01%)1.65 (0.87 to 3.12)
        >281263 (1.99%)5062 (1.34%)1.51 (1.42 to 1.61)
    Paroxetine
        0†3 (0%)8 (0%)2.29 (0.61 to 8.64)
        1–718 (0.03%)34 (0.01%)3.18 (1.80 to 5.63)
        8–1411 (0.02%)26 (0.01%)2.56 (1.26 to 5.18)
        15–2111 (0.02%)34 (0.01%)1.95 (0.99 to 3.85)
        22–2811 (0.02%)31 (0.01%)2.12 (1.06 to 4.21)
        >28816 (1.28%)3706 (0.98%)1.33 (1.23 to 1.43)
TCAs
    Any TCA
        0†9 (0.01%)25 (0.01%)2.28 (1.06 to 4.88)
        1–750 (0.08%)148 (0.04%)2.07 (1.50 to 2.86)
        8–1449 (0.08%)152 (0.04%)2.02 (1.46 to 2.78)
        15–2162 (0.1%)170 (0.04%)2.24 (1.68 to 3.01)
        22–2848 (0.08%)157 (0.04%)1.89 (1.37 to 2.62)
        >287369 (11.6%)33074 (8.73%)1.40 (1.36 to 1.43)
    Dothiepin
        0†4 (0.01%)12 (0%)2.05 (0.66 to 6.37)
        1–720 (0.03%)64 (0.02%)1.90 (1.15 to 3.14)
        8–1421 (0.03%)68 (0.02%)1.88 (1.15 to 3.07)
        15–2122 (0.03%)76 (0.02%)1.77 (1.10 to 2.84)
        22–2816 (0.03%)69 (0.02%)1.42 (0.83 to 2.46)
        >282843 (4.48%)13142 (3.47%)1.32 (1.26 to 1.38)
    Amitriptyline
        0†0 (0%)11 (0%)
        1–725 (0.04%)59 (0.02%)2.53 (1.58 to 4.05)
        8–1422 (0.03%)70 (0.02%)1.92 (1.19 to 3.11)
        15–2123 (0.04%)55 (0.01%)2.42 (1.48 to 3.95)
        22–2814 (0.02%)69 (0.02%)1.23 (0.69 to 2.19)
        >282543 (4.0%)11236 (2.97%)1.38 (1.32 to 1.44)
    Lofepramine
        0†6 (0.01%)5 (0%)7.25 (2.21 to 23.75)
        1–712 (0.02%)29 (0.01%)2.52 (1.29 to 4.94)
        8–1412 (0.02%)29 (0.01%)2.53 (1.29 to 4.96)
        15–2119 (0.03%)39 (0.01%)2.97 (1.71 to 5.13)
        22–2814 (0.02%)27 (0.01%)3.02 (1.57 to 5.79)
        >281331 (2.1%)5518 (1.46%)1.46 (1.37 to 1.55)