Table 2

 Changes in systemic arterial haemodynamic variables, AS haemodynamic variables, and LV function in the 10 pigs of group B during induction of severe supravalvar AS and SH. In this group, SH was induced by administration of phenylephrine

NormalSevere ASSevere AS + mild SHSevere AS + severe SH
*Significant difference v normal stage; †significant difference between severe stenosis + SH stages and the severe stenosis stage.
Systemic arterial haemodynamic variables
    Systolic aortic pressure (mm Hg)113 (13)107 (14)129 (15)*†162 (12)*†
    Diastolic aortic pressure (mm Hg)82 (12)72 (10)90 (14)†121 (12)*†
    Pulse pressure (mm Hg)32 (4)35 (9)39 (9)40 (10)
    Systemic arterial resistance (dyn.s/cm5)1512 (306)1406 (283)1628 (322)2392 (534)*†
    Systemic arterial compliance (ml/mm Hg)1.87 (0.32)1.69 (0.40)1.51 (0.43)*1.13 (0.24)*†
    Effective arterial elastance (mm Hg/ml)1.94 (0.42)2.02 (0.37)2.31 (0.46)3.37 (0.77)*†
Catheter derived AS haemodynamic variables
    Catheter derived EOA (cm2)2.50 (0.27)0.64 (0.19)*0.71 (0.22)*0.82 (0.34)*
    Catheter maximum gradient (mm Hg)2 (3)46 (19)*41 (14)*30 (12)*†
    Catheter mean gradient (mm Hg)1 (1)31 (14)*27 (10)*20 (9)*†
    Catheter peak to peak gradient (mm Hg)1 (1)37 (18)*29 (12)*†16 (11)*†
Doppler derived AS haemodynamic variables
    Doppler EOA (cm2)2.28 (0.27)0.51 (0.11)*0.56 (0.13)*0.66 (0.14)*†
    Aortic diameter (mm)20.1 (2.1)18.0 (1.6)*19.4 (1.8)21.0 (2.1)†
    Energy loss coefficient (cm2)2.47 (0.28)0.68 (0.27)*0.75 (0.27)*0.85 (0.29)*
    Doppler maximum gradient (mm Hg)6 (1)68 (20)*64 (20)*46 (13)*†
    Doppler mean gradient (mm Hg)3 (1)47 (15)*43 (12)*31 (9)*†
LV systolic function
    Heart rate (beats/min)90 (7)89 (7)95 (8)112 (16)*†
    Stroke volume (ml)54 (8)49 (8)51 (9)45 (9)
    Cardiac output (l/min)4.84 (0.86)4.37 (0.90)4.86 (1.16)4.85 (1.05)
    Mean systolic flow rate (ml/s)198 (23)162 (25)*175 (31)173 (27)*
    Peak LV systolic wall stress (kdyn/cm2)193 (45)268 (82)293 (81)*360 (66)*†