Clinical characteristics and macroscopic necropsy findings in study subjects by age
| Age group (years) | ||||
|---|---|---|---|---|
| 1 (20–40) (n = 15) | 2 (41–60) (n = 17) | 3 (⩾61) (n = 16) | p Value* | |
| Data are number of subjects or mean (SEM). | ||||
| *p Value between the three age groups. | ||||
| HDL, high density lipoprotein; NS, not significant | ||||
| Men/women | 10/5 | 13/4 | 9/7 | |
| Age (years) | 29.1 (1.6) | 49.8 (0.90) | 71.3 (1.1) | |
| Clinical history | ||||
| Coronary artery disease | 0 | 2 | 9 | <0.001 |
| Other atherosclerotic disease | 0 | 2 | 3 | <0.001 |
| Hypertension | 0 | 4 | 6 | <0.001 |
| Diabetes | 0 | 1 | 4 | <0.001 |
| Smoking | 1 | 1 | 4 | 0.031 |
| Cholesterol >6.0 mmol/l | 0 | 6 | 4 | NS |
| HDL cholesterol <1 mmol/l | 0 | 3 | 3 | NS |
| Necropsy findings (macroscopic) | ||||
| Aortic valve | ||||
| Normal | 15 | 14 | 9 | |
| Fatty changes | 0 | 3 | 4 | |
| Calcified | 0 | 0 | 2 | |
| Leaky | 0 | 0 | 1 | 0.008 |
| Coronary arteries | ||||
| Normal | 5 | 0 | 0 | |
| Fatty streaks | 8 | 3 | 3 | |
| Small atheromas (<50%) | 2 | 9 | 4 | |
| Significant atheromas (⩾50%) | 0 | 1 | 1 | |
| Complicated lesions | 0 | 4 | 8 | <0.001 |
| Acute myocardial infarction | 0 | 2 | 2 | NS |
| Number of affected coronary arteries | ||||
| 0 | 5 | 0 | 0 | |
| 1 | 0 | 1 | 3 | |
| ⩾2 | 9 | 10 | 12 | |
| Diffuse | 1 | 6 | 1 | NS |