Diagnostic information for the biochemical diagnosis of CHF
| Analyte | Cut off concentration (ng/l) | Sensitivity (95% CI) | Specificity (95% CI) | PPV | NPV | Diagnostic accuracy |
|---|---|---|---|---|---|---|
| *Approved cut off concentrations for the AxSYM BNP assay (100 ng/l) and Elecsys NT-proBNP assay (dual cut off 125 ng/l for patients <75 years of age and 450 ng/l for those ⩾75 years of age); †criterion concentrations corresponding to the highest diagnostic accuracy (that is, optimal cut off concentrations with minimum false negative and false positive results). | ||||||
| CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value. | ||||||
| BNP | 100* | 96% (92 to 99) | 61% (52 to 70) | 0.75 | 0.93 | 80% |
| 118 | 95% (90 to 98) | 64% (55 to 73) | 0.76 | 0.91 | 81% | |
| 160 | 90% (84 to 95) | 73% (64 to 81) | 0.80 | 0.87 | 83% | |
| 295† | 80% (73 to 87) | 86% (78 to 92) | 0.87 | 0.78 | 83% | |
| NT-proBNP | 292 | 95% (90 to 98) | 53% (43 to 62) | 0.71 | 0.90 | 76% |
| 125/450* | 94% (89 to 97) | 46% (37 to 56) | 0.68 | 0.87 | 73% | |
| 476 | 90% (84 to 95) | 65% (55 to 74) | 0.76 | 0.85 | 79% | |
| 825† | 87% (80 to 92) | 81% (72 to 88) | 0.84 | 0.84 | 84% | |