Table 4

 Predictors of (a) death and (b) death or readmission to hospital for heart failure and for preserved and reduced LVSF from a multivariate Cox proportional hazards regression model

FactorIncremental factorPreserved LVSFReduced LVSF
HR (95% CI)p ValueHR (95% CI)p Value
Data shown are the hazard ratio for the stated change in the factor with 95% confidence interval and associated p value.
(a) Death
Age5 years1.17 (0.99 to 1.37)0.0621.18 (1.08 to 1.30)0.0004
Haemoglobin20 g/l0.71 (0.52 to 0.96)0.0240.69 (0.56 to 0.84)0.0003
Sodium5 mmol/l0.69 (0.48 to 0.98)0.0350.82 (0.67 to 1.00)0.052
Neutrophils3×109/l1.10 (0.88 to 1.37)0.401.32 (1.19 to 1.47)<0.0001
Urea5 mmol/l1.53 (1.25 to 1.87)<0.00011.26 (1.14 to 1.38)<0.0001
SpironolactoneYes1.23 (0.56 to 2.72)0.611.87 (1.23 to 2.83)0.0032
Valve diseaseYes5.82 (2.43 to 14.0)<0.00012.82 (1.10 to 7.24)0.032
SexMale2.44 (1.25 to 4.79)0.00940.96 (0.67 to 1.38)0.83
Covariate with significant interactions with systolic function
COPDY11.6 (5.11 to 26.2)<0.00011.64 (0.94 to 2.88)0.084
Tests for interaction: COPD p = 0.0006
(b) Death or hospital readmission for HF
Age5 years1.06 (0.92 to 1.22)0.391.12 (1.04 to 1.21)0.0030
Haemoglobin20 g/l0.83 (0.62 to 1.12)0.220.73 (0.61 to 0.87)0.0006
Sodium5 mmol/l0.60 (0.43 to 0.84)0.00300.92 (0.76 to 1.12)0.42
Neutrophils3×109/l1.17 (0.94 to 1.45)0.151.25 (1.12 to 1.40)0.0001
SpironolactoneYes1.39 (0.65 to 2.94)0.401.96 (1.35 to 2.85)0.0004
Valve diseaseYes3.96 (1.67 to 9.38)0.00183.72 (1.68 to 8.24)0.0012
Covariates with significant interactions with systolic function:
COPDYes9.86 (4.48 to 21.7)<0.00011.61 (0.98 to 2.64)0.061
SexMale1.69 (0.91 to 3.15)0.0380.84 (0.60 to 1.16)0.29
Urea5 mmol/l1.81 (1.46 to 2.24)<0.00011.18 (1.07 to 1.29)0.0006
Tests for interaction: COPD p = 0.0002, sex p = 0.046, urea p = 0.0004