Baseline parameters
| Parameter | Placebo (n = 9) | BQ-123 (n = 9) | BQ-123 + BQ-788 (n = 9) |
|---|---|---|---|
| Data are mean (SEM). | |||
| CO, cardiac output; CVP, central venous pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PVR, pulmonary vascular resistance; SBP, systolic blood pressure; SVR, systemic vascular resistance. | |||
| HR (beats/min) | 64 (5) | 62 (4) | 63 (5) |
| MAP (mm Hg) | 91 (7) | 87 (6) | 90 (7) |
| SBP (mm Hg) | 106 (8) | 104 (9) | 106 (9) |
| DBP (mm Hg) | 69 (4) | 68 (6) | 71 (4) |
| CVP (mm Hg) | 5 (1) | 5 (1) | 3 (2) |
| CO (l/min) | 5.0 (0.3) | 5.5 (0.4) | 5.3 (0.3) |
| SVR (dyn.s/cm−5) | 1462 (150) | 1266 (138) | 1344 (138) |
| MPAP (mm Hg) | 16 (1) | 16 (1) | 17 (2) |
| PAWP (mm Hg) | 11 (2) | 11 (1) | 12 (3) |
| PVR (dyn.s/cm−5) | 83 (12) | 91 (14) | 78 (18) |