Baseline clinical characterisation of patients who underwent serial echocardiography
| FS at last evaluation | p Value | ||
|---|---|---|---|
| >25% | ⩽25% | ||
| Data are mean (SD (range) or number (%). | |||
| Number of patients | 440 (95.2%) | 22 (4.8%) | NA |
| Men/women | 278/162 | 12/10 | 0.4 |
| Age (years) | 41 (14) (16–79) | 41 (15) (19–71) | 0.8 |
| Age at diagnosis (years) | 36 (15) (3–78) | 35 (17) (11–71) | 0.6 |
| Follow up (months) | 64 (40) (12–192) | 100 (47) (16–193) | 0.007 |
| VF | 9 (2.0%) | 1 (4.5%) | NA |
| AF | 67 (15.2%) | 6 (27.3%) | 0.1 |
| Exertional chest pain | 126 (28.6%) | 10 (45.5%) | 0.07 |
| NYHA class | |||
| I | 269 (61.0%) | 13 (59.1%) | 0.2 |
| II | 159 (36.1%) | 8 (36.4%) | 1 |
| III–IV | 13 (2.9%) | 1 (4.5%) | NA |
| Family history of SCD | 134 (30.4%) | 8 (36.4%) | 0.5 |
| Palpitations | 115 (26.1%) | 7 (31.8%) | 0.3 |
| Syncope | 67 (15.2%) | 10 (45.5%) | 0.001 |
| Abnormal BP response | 131 (29.7%) | 15 (68.2%) | 0.001 |
| Non-sustained VT | 91 (20.6%) | 11 (50.0%) | 0.002 |
| Severe LVH | 42 (9.6%) | 4 (18.2%) | 0.3 |
| Risk factor SD | |||
| 0 | 164 (37.2%) | 2 (9.1%) | NA |
| 1 | 165 (37.4%) | 8 (36.4%) | NA |
| 2 | 89 (20.2%) | 6 (27.3%) | NA |
| 3 | 21 (4.8%) | 4 (18.2%) | NA |
| 4 | 1 (0.2%) | 2 (9.1%) | NA |
| 5 | 1 (0.2%) | 0 | <0.0001 |
| LVOTG | 108 (24.5%) | 3 (13.6%) | 0.3 |
| Wigle | 4.4 (2.6) (0–10) | 5.5 (2.2) (0–10) | 0.09 |
| MLVWT (mm) | 20.5 (6.1) (8–43) | 23.4 (6.0) (14–37) | 0.04 |
| LVEDD (mm) | 43.6 (5.9) (28–60) | 48.3 (6.7) (39–65) | 0.0003 |
| LVESD (mm) | 24.7 (5.4) (10–43) | 30.7 (6.5) (20–45) | <0.0001 |
| FS (%) | 43.3 (8.0) (26–72) | 36.7 (7.1) (27–48) | 0.0002 |
| LA diameter (mm) | 42.9 (8.2) (20–72) | 45.8 (6.4) (34–57) | 0.1 |