Table 2

 Classification of endothelin receptors

ETAETB
• Agonist potencyET-1>ET-2>>ET-3ET-1 = ET-2 = ET-3
• Selective agonistNoneEndothelin-3, sarafotoxin-6c, BQ3020, IRL1620
• Main actionsVasoconstrictionVasodilatation
MitogenesisVasoconstriction
AngiogenesisNatriuresis
Matrix formationET clearance