Table 8

 Effects of bosentan on efficacy of progestogen contraception

Contraceptive methodEffect of bosentan on contraceptive efficacyRecommendation for use in women with pulmonary vascular disease taking bosentan
POP (“minipill”)ReducedWHO 4, do not use
CerazetteReducedWHO 2 if double dose taken
LevonelleReducedWHO 2 if double dose taken
Depo ProveraNo effectWHO 1, no contraindication
Mirena IUSNo effectWHO 3, because of risk of vagal reaction at insertion in pulmonary hypertension
ImplanonReducedWHO 2 if additional daily Cerazette taken