Hazard ratios used in the recalibrated model with hazard ratios for CHD and CVD risk factors for BRHS, Caerphilly study, Speedwell study and BWHHS
| BRHS* (n = 7001) | Caerphilly (n = 2197) | Speedwell (n = 2028) | BWHHS† (n = 3144) | Model HR | |
|---|---|---|---|---|---|
| *Follow up was censored at 10 years in the men’s cohorts of the British Regional Heart Study (BRHS), the Caerphilly Study and the Speedwell Study. | |||||
| †The median follow up was 4.7 years (range 3.4–5.7 years) for women in the British Women’s Heart and Health Study (BWHHS) and the age group was older than in the men’s cohorts. | |||||
| ‡Coronary heart disease (CHD) and cardiovascular disease (CVD) excluded those with a prior diagnosis of myocardial infarction, stroke and diabetes from the analysis. | |||||
| HDL, high density lipoprotein; HR, hazard ratio; SBP, systolic blood pressure; TC, total cholesterol. | |||||
| Hazard ratio CHD‡ (95% CI) | |||||
| No of events | 493 | 199 | 165 | 160 | |
| Age (per 10 years) | 2.02 (1.71 to 2.38) | 1.59 (1.15 to 2.19) | 2.05 (1.41 to 2.98) | 1.54 (1.14 to 2.07) | 2.0 |
| Log (TC:HDL) | 4.05 (3.02 to 5.43) | 2.47 (1.67 to 3.63) | 2.33 (1.68 to 3.23) | 2.48 (1.53 to 4.03) | 2.5 |
| SBP (per 10 mm Hg) | 1.16 (1.12 to 1.21) | 1.14 (1.06 to 1.22) | 1.16 (1.09 to 1.23) | 1.07 (1.00 to 1.13) | 1.1 |
| Current smoker | 1.62 (1.36 to 1.94) | 1.78 (1.35 to 2.37) | 1.29 (0.94 to 1.75) | 2.01 (1.35 to 2.98) | 1.6 |
| Hazard ratio CVD‡ (95% CI) | |||||
| Number of events | 632 | 246 | 212 | 200 | |
| Age (per 10 years) | 2.15 (1.86 to 2.50) | 1.78 (1.33 to 2.38) | 2.21 (1.58 to 3.09) | 1.65 (1.26 to 2.16) | 2.1 |
| Log (TC:HDL) | 3.03 (2.32 to 3.65) | 2.12 (1.50 to 3.01) | 2.05 (1.52 to 2.76) | 2.20 (1.43 to 3.40) | 2.2 |
| SBP (per 10 mm Hg) | 1.20 (1.16 to 1.24) | 1.15 (1.08 to 1.22) | 1.19 (1.13 to 1.25) | 1.05 (0.99 to 1.11) | 1.2 |
| Current smoker | 1.81 (1.55 to 2.12) | 1.92 (149 to 2.48) | 1.40 (1.07 to 1.83) | 2.50 (1.79 to 3.50) | 1.8 |