Table 1

 Baseline characteristics and haemodynamic variables of patients with definite and possible DD and of normal controls

Definite DDPossible DDNormal controlsp Value*
Data are mean (SD) or percentage.
*Kruskal–Wallis analysis of variance for comparison between all three groups; †Bonferroni correction (p<0.0017 indicates significance).
ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker; BSA, body surface area; DBP, diastolic blood pressure; DD, diastolic dysfunction; EDV, end diastolic volume; ESV, end systolic volume; HDL, high density lipoprotein; LDL, low density lipoprotein; PP, pulse pressure; SBP, systolic blood pressure.
Number4410982
Age (years)65.7 (10.1)61.7 (10.6)55.6 (8.9)<0.000001†
Men50%55.9%71.9%0.02
Hypertension81.8%75.2%45.1%<0.000001†
Diabetes22.7%15.6%11.0%0.22
Dyspnoea65.9%55.0%35.4%0.002
Pulmonary disease11.3%13.8%14.6%0.88
Coronary artery disease54.5%42.2%31.7%0.04
Ejection fraction (%)72.2 (8.2)72.8 (8.4)70.9 (8.9)0.50
Angiographic EDV (ml)131.3 (38.3)136.3 (40.0)133.9 (32.0)0.85
EDV/BSA (ml/m2)70.0 (17.1)69.9 (18.5)67.1 (14.9)0.85
Angiographic ESV (ml)40.3 (24.7)37.5 (20.1)39.3 (17.6)0.76
Total cholesterol (mmol/l)5.40 (1.18)5.43 (1.18)5.48 (1.19)0.86
LDL cholesterol (mmol/l)3.13 (1.10)3.18 (1.01)3.29 (1.07)0.72
HDL cholesterol (mmol/l)1.39 (0.40)1.45 (0.44)1.35 (0.42)0.33
Triglycerides (mmol/l)1.96 (0.03)1.84 (0.99)2.09 (1.58)0.62
Creatinine clearance (ml/s)1.17 (0.39)1.37 (0.51)1.57 (0.47)0.000009†
Body height (cm)166.8 (9.1)168.8 (8.8)171.4 (8.1)0.007
SBP brachial (mm Hg)142.9 (21.4)140.8 (20.7)130.5 (17.6)0.0002†
DBP brachial (mm Hg)78.4 (11.5)83.3 (13.6)80.1 (11.7)0.10
PP brachial (mm Hg)65.5 (15.8)57.9 (15.3)50.5 (13.9)0.000003†
SBP aortic (mm Hg)134.2 (21.2)131.3 (20.3)120.1 (17.0)0.00002†
DBP aortic (mm Hg)79.3 (11.7)84.1 (13.7)80.9 (11.8)0.10
PP aortic (mm Hg)54.9 (15.5)47.6 (14.5)39.5 (13.2)<0.000001†
Aspirin88.6%75.2%73.2%0.12
β blockers72.7%56.9%46.3%0.02
Calcium channel blockers25%17.4%8.5%0.04
ACE inhibitor/ARB50%51.4%35.4%0.07
Nitrates22.7%11.9%14.6%0.24
Statins34.1%29.4%34.1%0.74
Diuretics31.8%25.7%18.3%0.22