Table 1

‚ÄÉChanges in cardiac function, mass and volume in 15 patients with pulmonary arterial hypertension treated with bosentan for one year with sildenafil added for three months

VariableBaseline12 months bosentan12 months bosentan + 3 months combination
Data are mean (SD).
*p<0.05; **p<0.01.
LV, left ventricular; LVEDV, left ventricular end diastolic volume; LVEF, left ventricular ejection fraction; RV, right ventricular; RVEDV, right ventricular end diastolic volume; RVEF, right ventricular ejection fraction.
Cardiac index (l/min/m2)2.0 (0.7)2.3 (0.6)2.8 (1.1)**
Stroke volume index (ml/m2)30 (16)32 (14)36 (18)
RVEF (%)33 (16)39 (24)43 (19)*
LVEF (%)62 (22)70 (20)70 (20)
RV mass (g)87 (37)109 (36)101 (33)**
LV mass (g)129 (37)132 (28)133 (32)
RVEDV (ml)162 (34)174 (58)153 (28)
LVEDV (ml)83 (15)82 (27)86 (26)
RVEDV:LVEDV ratio2.1 (0.6)2.4 (0.9)2.0 (0.6)**