Clinical and echocardiographic characteristics
| Aortic stenosis | Controls | p Value | |
|---|---|---|---|
| Data are mean (interquartile range) except age (median (range)). | |||
| β, rise in signal intensity; BSA, body surface area; CBF, coronary blood flow; CBFV, coronary blood flow velocity; CBFVI, coronary blood flow velocity index (corrected for left ventricular mass); LV, left ventricular; LVMI, left ventricular mass index (corrected for body surface area; MCE, myocardial contrast echocardiography; NA, not applicable; NS, not significant; SI, signal intensity. | |||
| Men | 2 (40%) | 2 (40%) | NS |
| Age (years) | 70 (67–81) | 62 (54–71) | NS |
| Hypertension | 5 (45%) | 2 (40%) | NS |
| Diabetes | 0 (0%) | 1 (20%) | NS |
| Aortic valve area (mm2) | 0.6 (0.4–0.7) | NA | NA |
| Corrected for BSA | 0.3 (0.2–0.4) | NA | NA |
| Transvalvar gradient (mm Hg) | |||
| Peak | 93 (79–104) | NA | NA |
| Mean | 58 (48–67) | NA | NA |
| LV ejection fraction (%) | 61 (58–71) | 65 (60–68) | NS |
| End diastolic volume (ml) | 86 (70–108) | 85 (70–90) | NS |
| Corrected for BSA | 50 (40–57) | 48 (40–55) | NS |
| End systolic volume (ml) | 30 (24–38) | 30 (26–40) | NS |
| Corrected for BSA | 18 (14–21) | 18 (15–22) | NS |
| LV mass (g) | 286 (262–319) | 142 (137–153) | <0.001 |
| LVMI | 163 (145–178) | 79 (76–85) | <0.001 |
| Diastolic CBFV (cm/s) | 26 (22–35) | 20 (19–22) | NS |
| CBFVI | 0.100 (0.07–0.115) | 0.130 (0.130–0.160) | 0.002 |
| CBF reserve | 1.6 (1.3–1.9) | 2.6 (2.5–2.7) | <0.001 |
| SI at MCE | 21 (14–52) | 64 (63–66) | 0.002 |
| Replenishment time (μs) | 1198 (853–2013) | 794 (700–1064) | NS |
| β | 0.89 (0.53–1.15) | 1.3 (1.1–1.5) | NS |
| SI*β (1/s) | 11 (8–66) | 83 (73–95) | 0.001 |