Table 1

 Clinical characteristics of lamin A/C mutation carriers

Family and memberSex and age (years)LVEDD (mm)EF (%)AVB or slow AFPMVTComments
AF, atrial fibrillation; AVB, atrioventricular block; EF, ejection fraction; F, female; HT, heart transplantation; ICD, implantable cardioverter-defibrillator; LA, left atrium; LAHB, left anterior hemiblock; LBBB, left bundle branch block; LVEDD, left ventricular end diastolic diameter; LVH, left ventricular hypertrophy; M, male; NYHA, New York Heart Association functional class; PM, pacemaker; SVT, supraventricular tachycardia; VT, ventricular tachycardia.
A II: 2M 476725AFYesNoHT
A II: 3M 455342AFYesNoNYHA II
A II: 5F 4946621° AVBNoNoBradycardia, palpitations
A III: 1M 215363NoNoNoLVH
B II: 2F 623966NoNoNoSyncope
B II: 3M 586411NoNoNoHT
B II: 5M 565941NoNoNoNone
B III: 1M 406120NoNoNoRecurrent AF, ablation ×3
B III: 5F 304465NoNoNoNone
B III: 6M 265756NoNoNoSyncope, palpitations
C III: 4M 4557282° AVBYesNoHT
D II: 2F 575533AFYesYesICD
D II: 4M 4053681° AVBNoNoNone
D III: 2M 3751551° AVBNoNoNone
E II: 3M 466929AFYesYesHT
F II: 2M 328322NoNoYesHT
G II: 2M 5661212° AVBYesYesSVT, HT
G II: 4F 5556361° AVB, LBBBNoNoNone
G II: 5F 5153561° AVB, LAHBNoNoNone
G III: 2M 295459NoNoNoLVH, LA size ↑
G III: 3F 2749701° AVBNoNoLA size ↑
G III: 5F 204667NoNoNoNone