Unadjusted and adjusted odds ratios (ORs) comparing cases with controls according to the timing of the last prescription during the period before the index date
| Unadjusted OR | 95% CI | Adjusted OR* | 95% CI | p Value | |
|---|---|---|---|---|---|
| *Adjusted for co-morbidity (diabetes, hypertension, CCF, myocardial infarction, cancer), angiotensin converting enzyme inhibitors, aspirin, β blockers, calcium channel blockers, smoking, body mass index, and deprivation (Townsend score in fifths). Adjusted odds ratios for individual statins were also adjusted for other statins. | |||||
| Any statin | |||||
| Not prescribed drug | 1.00 | 1.00 | |||
| Last script >90 days before index date | 1.80 | 1.42 to 2.28 | 1.24 | 0.93 to 1.65 | 0.136 |
| Last script ⩽90 days before index date | 0.53 | 0.46 to 0.61 | 0.61 | 0.52 to 0.72 | <0.001 |
| Atorvastatin | |||||
| Not prescribed drug | 1.00 | 1.00 | |||
| Last script >90 days before index date | 1.43 | 1.02 to 1.99 | 1.20 | 0.81 to 1.78 | 0.376 |
| Last script ⩽90 days before index date | 0.56 | 0.45 to 0.69 | 0.62 | 0.48 to 0.79 | <0.001 |
| Cerivastatin | |||||
| Not prescribed drug | 1.00 | 1.00 | |||
| Last script >90 days before index date | 1.12 | 0.73 to 1.72 | 1.20 | 0.72 to 2.00 | 0.480 |
| Last script ⩽90 days before index date | 0.62 | 0.32 to 1.23 | 0.59 | 0.26 to 1.37 | 0.220 |
| Fluvastatin | |||||
| Not prescribed drug | 1.00 | 1.00 | |||
| Last script >90 days before index date | 0.78 | 0.39 to 1.56 | 0.75 | 0.35 to 1.63 | 0.467 |
| Last script ⩽90 days before index date | 0.48 | 0.25 to 0.93 | 0.59 | 0.29 to 1.20 | 0.144 |
| Pravastatin | |||||
| Not prescribed drug | 1.00 | 1.00 | |||
| Last script >90 days before index date | 0.70 | 0.35 to 1.43 | 0.68 | 0.31 to 1.50 | 0.339 |
| Last script ⩽90 days before index date | 0.65 | 0.40 to 1.06 | 0.51 | 0.30 to 0.87 | 0.013 |
| Simvastatin | |||||
| Not prescribed drug | 1.00 | 1.00 | |||
| Last script >90 days before index date | 1.14 | 0.89 to 1.46 | 0.95 | 0.70 to 1.30 | 0.758 |
| Last script ⩽90 days before index date | 0.61 | 0.51 to 0.72 | 0.62 | 0.50 to 0.76 | <0.001 |