Table 1

 Studies examining the relation of obesity and overweight with longer term mortality, recurrent coronary heart disease (CHD), and stroke in patients with existing CHD

Study (reference)Study descriptionOutcomeMain findings
All studies used a cohort design; assessment of obesity and overweight was based on body mass index (BMI); follow up was at least one year after study recruitment.
CVD, cardiovascular disease; MI, myocardial infarction.
Physicians’ health study135010 men (age not reported) with self reported CHD or stroke; BMI categorised into 4 groups913 deaths comprising 703 CVD deaths after mean of 5 years’ surveillanceReverse “J” shaped relation of BMI groups with total and CVD mortality
Group health cooperative152677 men and women aged 30 to 79 years with a hospital admission for MI; BMI categorised into quintiles431 deaths; 445 reinfarctions (fatal and non-fatal); 124 strokes (fatal or non-fatal) after mean of 3.4 years’ surveillanceRelation of BMI with CHD was “J” shaped, null with stroke (estimates not reported), and reverse “J” shaped with total mortality
Diet and reinfarction trial162033 men (age not reported) with a hospital discharge record for MI; BMI categorised into quartiles1083 deaths comprising 739 CHD deaths after up to 17 years’ surveillanceReverse “J” shaped relation of BMI with total and CHD mortality
Group health cooperative12691 women aged 66.2 years (mean) with a hospital discharge record for MI; BMI categorised into thin, normal weight, overweight, and obese166 deaths and 127 reinfarctions (fatal and non-fatal) after up to 13 years’ surveillanceBMI positively related to reinfarction; BMI–total mortality association “U” shaped
San Diego and Vancouver study141760 men and women (age and sex distribution not reported) with a hospital admission for acute MI; BMI categorised into normal weight, overweight, and underweightMortality and reinfarction after 12 months (numbers not reported)Relation of BMI categories inverse for mortality and null for reinfarction