Comparisons of clinical features and outcomes in selected natural history studies
| Author | Date | No | Age (years) | FU (years) | All cause* | SD* | HF* | CVA* | NYHA ⩾III | LVOTG | ICD | Myec | Amio | Dx |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| *Annual rate (%); †left ventricular outflow tract gradient (LVOTG) at rest or provokable. | ||||||||||||||
| All cause, all cause mortality; Amio, amiodarone; B, biopsy; Cl, Clinical; Ct, catheterisation; CVA, ischaemic cardiovascular accident related death; Date, publication date; Dx, means of diagnosis; E, echocardiography; FU, Follow up; HF, heart failure death or heart transplantation; ICD, implantable cardioverter-defibrillator; Myec, myotomy-myectomy; No, number of patients; NYHA, New York Heart Association functional class; SD, sudden cardiac death; SGH 88-02; Saint George’s Hospital 1988–2002. | ||||||||||||||
| Braunwald2 | 1964 | 64 | 26 | 1.8 | 6.1 | 1.7 | 1.7 | 0.0 | 33% | 69%† | 16% | Cl+Ct | ||
| Hardarson3 | 1973 | 119 | 30 | 4.6 | 5.5 | 3.5 | 0.2 | 0.2 | 15% | 58%† | 18% | 0 | Cl+E+Ct | |
| Shah4 | 1974 | 190 | 34 | 5.2 | 5.0 | 2.6 | 0.2 | 36% | 74%† | 30% | E | |||
| Ceci26 | 1978 | 100 | 40 | 8.2 | 1.2 | 0.7 | 0.2 | 49% | Ct+E | |||||
| Maron20 | 1981 | 99 | 38 | 3.0 | 2.4 | 2.0 | 0.3 | 18% | 54% | 15% | 0 | E | ||
| McKenna25 | 1981 | 254 | 34 | 5.7 | 4.0 | 2.2 | 0.4 | 0.1 | 9% | 65% | 13% | Cl+E+Ct | ||
| Loogen27 | 1983 | 339 | 38 | 4.8 | 2.8 | 27% | 66% | 27% | E+Ct+B | |||||
| Shapiro16 | 1983 | 39 | 55 | 3.1 | 0.0 | 0.0 | 0.0 | 0.0 | 21% | 20%† | E | |||
| Koga28 | 1984 | 136 | 38 | 5.1 | 3.0 | 2.0 | 0.3 | 0.3 | 30% | 24% | 1% | E+Ct | ||
| Spirito6 | 1989 | 25 | 44 | 4.4 | 0.0 | 0.0 | 0.0 | 0.0 | 4% | 20% | 0 | E+Ct | ||
| Romeo29 | 1990 | 125 | 34 | 7.6 | 3.2 | 2.2 | 0.6 | 62% | 34%† | 0 | 0 | Cl+E | ||
| Pelliccia30 | 1991 | 116 | 37 | 9.0 | 2.8 | 2.3 | 27% | 34% | 0 | E | ||||
| Kofflard31 | 1993 | 113 | 37 | 7.3 | 1.6 | 1.1 | 0.1 | 14% | 34%† | 30% | E | |||
| Cecchi7 | 1995 | 202 | 41 | 10.0 | 0.7 | 0.1 | 0.5 | 10% | 20% | 2% | 31% | E | ||
| Cannan32 | 1995 | 37 | 59 | 7.6 | 3.6 | 1.1 | 11% | 75% | 6% | 3% | E | |||
| Maron8 | 1999 | 277 | 47 | 8.1 | 2.0 | 0.8 | 0.4 | 0.2 | 9% | 31% | 4% | 10% | 5% | E |
| Elliott18 | 2000 | 368 | 37 | 3.6 | 2.9 | 1.7 | 0.5 | 3% | 22% | 2% | 21% | E | ||
| Maron9 | 2000 | 744 | 45 | 8.0 | 2.1 | 0.7 | 0.5 | 0.2 | 19% | 22% | 2% | 5% | 14% | E |
| Spirito24 | 2000 | 480 | 47 | 6.5 | 2.3 | 0.7 | 0.5 | 7% | 28% | 3% | 5% | 6% | E | |
| Elliott19 | 2001 | 630 | 37 | 4.9 | 2.9 | 1.3 | 0.6 | 4% | 23% | 4% | 3% | 28% | E | |
| SGH 88–02 | 2003 | 956 | 42 | 5.8 | 2.3 | 1.0 | 0.5 | 0.1 | 3% | 26% | 5% | 3% | 34% | E |