Results of Cox proportional hazards regression models investigating factors associated with overall survival
| Factor | Variable | Single variable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p Value | HR | 95% CI | p Value | ||
| HR, hazard ratio; mPAP, mean pulmonary artery pressure; PVR, pulmonary vascular resistance. | |||||||
| Treatment group | Current treatment era | 0.46 | 0.23 to 0.92 | 0.028 | 0.40 | 0.19 to 0.84 | 0.016 |
| Historical control | 1.00 | 1.00 | |||||
| Baseline mPAP (mm Hg) | Per 10 mm Hg higher | 1.46 | 1.13 to 1.88 | 0.0038 | 1.21 | 0.71 to 2.07 | 0.48 |
| Baseline PVR (dyn·s·cm−5) | Per 100 dyn·s·cm−5 increase | 1.11 | 1.03 to 1.20 | 0.0075 | 1.04 | 0.89 to 1.21 | 0.63 |
| WHO class | III | 0.52 | 0.29 to 0.96 | 0.036 | 0.64 | 0.32 to 1.27 | 0.20 |
| IV | 1.00 | 1.00 | |||||