Table 3

 Results of Cox proportional hazards regression models investigating factors associated with overall survival

FactorVariableSingle variable analysisMultivariable analysis
HR95% CIp ValueHR95% CIp Value
HR, hazard ratio; mPAP, mean pulmonary artery pressure; PVR, pulmonary vascular resistance.
Treatment groupCurrent treatment era0.460.23 to 0.920.0280.400.19 to 0.840.016
Historical control1.001.00
Baseline mPAP (mm Hg)Per 10 mm Hg higher1.461.13 to 1.880.00381.210.71 to 2.070.48
Baseline PVR (dyn·s·cm−5)Per 100 dyn·s·cm−5 increase1.111.03 to 1.200.00751.040.89 to 1.210.63
WHO classIII0.520.29 to 0.960.0360.640.32 to 1.270.20