Table 4

 Changes in haemodynamic function from baseline to follow-up cardiac catheterisation in historical controls and bosentan treated patients

FactorVariableCurrent treatment eraHistorical controlp Value*
Mean95% CIMean95% CI
*p Values calculated two-sample t test.
mPAP, mean pulmonary arterial pressure; PVR, pulmonary vascular resistance; RAP, right atrial pressure.
mRAP (mm Hg)Value at baseline7.735.75 to 8.347.045.91 to 9.55
Absolute change at follow-up1.50−0.50, to 3.500.16−1.58 to 4.81
% change at follow-up89%−7.2% to 184%45%−54.3% to 136%0.51
mPAP (mm Hg)Value at baseline40.0036.53 to 43.4840.1136.81 to 43.41
Absolute change at follow-up1.08−2.05 to 4.201.44−1.54 to 4.41
% change at follow-up3.3%−5.3% to 12%6.1%−2.26% to 14%0.64
PVR (dyn·s·cm−5)Value at baseline612.95508.22 to 717.68597.31486.39 to 702.23
Absolute change at follow-up−15.74−96.10 to 64.62147.345.47 to 289. 22
% change at follow-up−1.4%−13% to 10%38%13% to 63%0.0058
Cardiac index (l/min/m2)Value at baseline2.602.40 to 2.812.732.47 to 2.99
Absolute change at follow-up0.044−0.19 to 0.28−0.22−0.50 to 0.06
% change at follow-up3.7%−5.1% to 13%−5.2%−15.2% to 4.7%0.17