Theoretical comparison of mean transvalvar pressure gradient in five hypothetical patients receiving the same prosthetic valve but having different body surface areas
| Patient number | |||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| For this simulation, mean pressure gradient was calculated assuming a cardiac index of 3 l/min/m2, a heart rate of 65 beats/min, and a systolic ejection time of 300 ms. | |||||
| EOA, effective orifice area. | |||||
| Reproduced and modified from Pibarot and Dumesnil5 with permission of Remedica Publishing. | |||||
| Body surface area (m2) | 1.5 | 1.75 | 2.0 | 2.25 | 2.5 |
| Cardiac output (l/min) | 4.5 | 5.25 | 6.0 | 6.75 | 7.5 |
| Valve EOA (cm2) | 1.3 | 1.3 | 1.3 | 1.3 | 1.3 |
| Mean pressure gradient (mm Hg) | 13 | 17 | 22 | 28 | 35 |