Table 5

 Echocardiographic characteristics of participants with normal EF by diastolic function status

Normal* (n = 755)Diastolic dysfunction, normal EF†p Value
Mild (n = 299)Moderate to severe (n = 72)
*Ejection fraction (EF) >50%, no regional wall motion abnormalities and normal diastolic function; †EF >50% and no regional wall motion abnormalities.
BNP, B-type natriuretic peptide; LV, left ventricular; LVEDD, left ventricular end diastolic diameter.
Age (years)68 (6)71 (7)73 (6)<0.0001
Women394 (52.2%)165 (55.2%)38 (54.3%)0.34
General health status score (/100)69 (22)63 (24)54 (26)<0.0001
LV EF (%)68 (5)67 (5)66 (7)0.11
Mitral annular systolic velocity (cm/s)10.6 (3)10.8 (3)8.4 (2)<0.0001
LVEDD index (cm/m2)2.67 (0.3)2.68 (0.4)2.70 (0.3)0.31
LV mass index (g/m)100 (24)106 (31)121 (33)<0.0001
Left atrial volume index (ml/m2)22.4 (6.6)23.4 (8.3)37.5 (14)<0.0001
Mitral annular diastolic velocity (cm/s)10.1 (2)8.6 (2)8.5 (2.8)<0.0001
Amino-terminal pro-BNP (pmol/l)14 (13)19 (31)105 (164)<0.0001