Patient characteristics according to homocysteine tertiles at baseline
| T1 (n = 724) | T2 (n = 734) | T3 (n = 711) | |
|---|---|---|---|
| *Mean (standard deviation, SD) or #median with interquartile range; †still smoking or drinking or recently stopped smoking or drinking; ‡fasting serum glucose ⩾7.0 mmol/l or self-reported diabetes. | |||
| Homocysteine, μmol/l* | 9.8 (SD 1.3) | 13.3 (SD 1.0) | 20.4 (SD 8.5) |
| Male gender, % (n) | 69 (503) | 78 (576) | 86 (610) |
| Age, years* | 56.8 (SD 9.8) | 59.3 (SD 9.8) | 62.8 (SD 10.4) |
| Body mass index, kg/m2* | 26.7 (SD 3.8) | 26.8 (SD 3.8) | 26.4 (SD 3.6) |
| Smoking†, % (n) | 30.9 (224) | 32.3 (237) | 34.0 (242) |
| Alcohol use†, % (n) | 73.1 (529) | 65.7 (482) | 68.5 (487) |
| Total cholesterol, mmol/l* | 5.3 (SD 1.1) | 5.3 (SD 1.2) | 5.3 (SD 1.0) |
| Diabetes mellitus‡, % (n) | 22 (161) | 19 (139) | 20 (139) |
| Creatinine clearance, ml/min (Cockroft) | 86.0 (SD 17.8) | 79.3 (SD 18.4) | 67.2 (SD 20.8) |
| Glucose-lowering agents, % (n) | 13 (96) | 10 (74) | 10 (70) |
| Blood pressure-lowering agents, % (n) | 27 (193) | 31 (229) | 41 (290) |
| Lipid-lowering agents, % (n) | 15 (110) | 15 (111) | 17 (118) |
| Metabolic syndrome, % (n) | 43.5 (315) | 40.5 (289) | 44.8 (328) |
| Metabolic syndrome components | |||
| Waist circumference, cm* | 94.7 (SD 10.7) | 97.0 (SD 10.5) | 96.9 (SD 10.6) |
| Blood pressure systolic, mm Hg* | 138 (SD 22) | 139 (SD 20) | 144 (SD 23) |
| Blood pressure diastolic, mm Hg* | 80 (SD 11) | 80 (SD 11) | 81 (SD 12) |
| HDL-cholesterol, mmol/l# | 1.16 (0.96–1.40) | 1.14 (0.94–1.39) | 1.16 (0.93–1.38) |
| Triglycerides, mmol/l# | 1.6 (1.1–2.2) | 1.6 (1.1–2.2) | 1.6 (1.2–2.4) |
| Fasting glucose, mmol/l* | 6.4 (SD 2.3) | 6.3 (SD 1.8) | 6.2 (SD 1.6) |