Estimated marginal mean (SE) of the different inflammatory variables according to the quintiles of resting heart rate, with the one-way ANOVA between the quintiles in the cohort
| 1st quintile n = 876 HR⩽58 | 2nd quintile n = 964 59⩽HR⩽65 | 3rd quintile n = 830 66⩽HR ⩽71 | 4th quintile n = 953 72⩽HR ⩽78 | 5th quintile n = 930 HR⩾79 | ANOVA | Pairwise comparison using Bonferroni correction | p Value | p for linear trend | |
|---|---|---|---|---|---|---|---|---|---|
| ANOVA, analysis of variance; HR, heart rate; hs-CRP, high-sensitivity C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein. | |||||||||
| *All results are adjusted for age, waist, body mass index, complete lipid profile including LDL, HDL and triglycerides, diastolic and systolic blood pressure measurements, haemoglobin concentration, glucose concentration, alcohol consumption, sport intensity, medications including nitrates, α blockers, β blockers, calcium channel blockers, angiotensin converting enzymes inhibitors, angiotensin II receptor blockers, statins, fibrates, digoxin, antiarrhythmic drugs, and cardiovascular risk factors, including current and past smoking status, diabetes mellitus, family history of coronary heart disease and history of proven vascular disease, including myocardial infarction, cerebrovascular accident or peripheral vascular disease. | |||||||||
| Fibrinogen (μmol/l) | 7.38 (0.62) | 7.53 (0.62) | 7.64 (0.62) | 7.85 (0.62) | 8.11 (0.62) | <0.001 | 1–3 | 0.001 | <0.001 |
| 1, 2–4, 5 | <0.001 | ||||||||
| 3–4 | 0.043 | ||||||||
| 3–5 | <0.001 | ||||||||
| 4–5 | 0.009 | ||||||||
| Polymorphonuclear count (×109/l) | 4.23 (0.48) | 4.39 (0.48) | 4.38 (0.48) | 4.47 (0.48) | 4.74 (0.48) | <0.001 | 1–2 | 0.041 | <0.001 |
| 1–4 | <0.001 | ||||||||
| 1, 2, 3, 4–5 | <0.001 | ||||||||
| hs-CRP (mg/l) | 1.12 (1.42) | 1.26 (1.43) | 1.31 (1.43) | 1.46 (1.43) | 1.61 (1.43) | <0.001 | 1–2 | 0.050 | <0.001 |
| 1–3 | 0.004 | ||||||||
| 1–4, 5 | <0.001 | ||||||||
| 2–4 | 0.003 | ||||||||
| 2, 3–5 | <0.001 | ||||||||