HR* (95% CI) | p Value | Missing teeth | HR* (95% CI) | p Value | Fractional polynomial† | HR* (95% CI) | p Value | |
---|---|---|---|---|---|---|---|---|

*Adjusted for age at examination, year of birth, gender, smoking status, body mass index, systolic blood pressure, father’s socioeconomic status | ||||||||

†x, (the number of missing teeth+1)/10; fp1, the first fractional polynomial term; fp2, the second fractional polynomial term. | ||||||||

‡Test for trend. | ||||||||

§Likelihood ratio test for the interaction between examined ages and number of missing teeth. | ||||||||

CVD (n = 509)
| ||||||||

All students ⩽30 years | ||||||||

For each additional missing tooth | 1.01 (0.99 to 1.03) | 0.372 | 0–4 | 1 | 0.024‡ | |||

5–9 | 1.14 (0.94 to 1.39) | 0.186 | fp1(x−0.51) | 2.08 (1.19 to 3.62) | 0.010 | |||

9+ | 1.35 (1.03 to 1.77) | 0.030 | fp2(◯2−0.26) | 0.72 (0.54 to 0.96) | 0.023 | |||

Interaction§ | 0.097 | |||||||

Students 16–19 years | ||||||||

For each additional missing tooth | 1.05 (1.01 to 1.10) | 0.023 | 0–4 | 1.00 | 0.003‡ | |||

5–9 | 1.26 (0.87 to 1.82) | 0.222 | fp1(◯3–0.12) | 2.12 (1.34 to 3.36) | 0.001 | |||

9+ | 2.24 (1.36 to 3.70) | 0.002 | fp2(◯3*ln(x)+0.08) | 0.33 (0.13 to 0.87) | 0.024 | |||

Students 20–23 years | ||||||||

For each additional missing tooth | 1.00 (0.97 to 1.04) | 0.915 | 0–4 | 0.600‡ | ||||

5–9 | 1.05 (0.78 to 1.46) | 0.684 | fp1(◯−2–4.10) | 1.00 (0.99 to 1.00) | 0.129 | |||

9+ | 1.10 (0.68 to 1.82) | 0.680 | fp2(◯3–0.12) | 0.95 (0.85 to 1.06) | 0.326 | |||

Students 24–30 years | ||||||||

For each additional missing tooth | 1.00 (0.97 to 1.03) | 0.979 | 0–4 | 1.00 | 0.325‡ | |||

5–9 | 1.17 (0.82 to 1.67) | 0.390 | fp1(◯−2–2.57) | 0.94 (0.87 to 1.02) | 0.134 | |||

9+ | 1.20 (0.79 to 1.85) | 0.394 | fp2(◯2*ln(x)+1.21) | 0.97 (0.94 to 1.01) | 0.131 | |||

CHD (n = 349)
| ||||||||

All students ⩽30 years | ||||||||

For each additional missing tooth | 1.01 (0.98 to 1.03) | 0.661 | 0–4 | 1.00 | 0.160‡ | |||

5–9 | 1.18 (0.94 to 1.50) | 0.159 | fp1(◯2–0.26) | 1.65 (0.98 to 2.77) | 0.060 | |||

9+ | 1.19 (0.84 to 1.69) | 0.319 | fp2(◯3–0.13) | 0.78 (0.60 to 1.01) | 0.064 | |||

Interaction§ | 0.122 | |||||||

Students 16–19 years | ||||||||

For each additional missing tooth | 1.04 (0.99 to 1.10) | 0.100 | 0–4 | 1.00 | 0.019‡ | |||

5–9 | 1.31 (0.86 to 2.00) | 0.215 | fp1(◯3–0.12) | 1.94 (1.14 to 3.31) | 0.015 | |||

9+ | 2.04 (1.11 to 3.72) | 0.020 | fp2(◯3*ln(x)+0.08) | 0.38 (0.13 to 1.11) | 0.076 | |||

Students 20–23 years | ||||||||

For each additional missing tooth | 1.00 (0.96 to 1.05) | 0.963 | 0–4 | 1.00 | 0.538‡ | |||

5–9 | 1.14 (0.80 to 1.67) | 0.439 | fp1(◯3–0.12) | 1.17 (0.80 to 1.73) | 0.415 | |||

9+ | 1.08 (0.59 to 1.98) | 0.808 | fp2(◯3*ln(x)+0.08) | 0.82 (0.53 to 1.25) | 0.349 | |||

Students 24–30 years | ||||||||

For each additional missing tooth | 0.99 (0.95 to 1.03) | 0.628 | 0–4 | 1.00 | 0.796‡ | fp1(◯−2–2.57) | 0.95 (0.86 to 1.06) | 0.363 |

5–9 | 1.09 (0.70 to 1.70) | 0.712 | fp2(◯2*ln(x)+1.21) | 0.98 (0.94 to 1.02) | 0.338 | |||

9+ | 0.87 (0.48 to 1.56) | 0.642 | ||||||

Stroke (n = 102)
| ||||||||

All students ⩽30 years | ||||||||

For each additional missing tooth | 1.02 (0.98 to 1.06) | 0.409 | 0–4 | 1.00 | 0.222‡ | |||

5–9 | 0.88 (0.55 to 1.41) | 0.599 | fp1(◯–2–3.88) | 1.00 (0.99 to 1.00) | 0.236 | |||

9+ | 1.64 (0.96 to 2.80) | 0.072 | fp2(◯3–0.13) | 1.01 (0.94 to 1.08) | 0.763 | |||

Interaction§ | 0.606 | |||||||

Students 16–19 years | ||||||||

For each additional missing tooth | 1.04 (0.93 to 1.17) | 0.485 | 0–4 | 1.00 | 0.478‡ | |||

5–9 | 0.95 (0.37 to 2.47) | 0.917 | fp1(◯3–0.12) | 1.83 (0.64 to 5.19) | 0.258 | |||

9+ | 1.96 (0.56 to 6.84) | 0.292 | fp2(◯3*ln(x)+0.08) | 0.49 (0.09 to 2.64) | 0.410 | |||

Students 20–23 years | ||||||||

For each additional missing tooth | 0.96 (0.87 to 1.06) | 0.431 | 0–4 | 1.00 | 0.166‡ | |||

5–9 | 0.56 (0.25 to 1.33) | 0.201 | fp1(◯–2–4.10) | 0.98 (0.96 to 1.00) | 0.036 | |||

9+ | 0.53 (0.13 to 2.23) | 0.387 | fp2(x–0.49) | 0.2 (0.04 to 1.05) | 0.058 | |||

Students 24–30 years | ||||||||

For each additional missing tooth | 1.04 (0.98 to 1.09) | 0.168 | 0–4 | 1.00 | 0.010‡ | |||

5–9 | 1.43 (0.66 to 3.11) | 0.369 | fp1(x−0.51) | 0.84 (0.70 to 1.01) | 0.067 | |||

9+ | 2.79 (1.30 to 5.97) | 0.008 | fp2(◯2–0.26) | 0.93 (0.86 to 1.01) | 0.074 | |||

Cancer (n = 549)
| ||||||||

All students ⩽30 years | ||||||||

For each additional missing tooth | 1.00 (0.98 to 1.02) | 0.858 | 0–4 | 1.00 | 0.763‡ | |||

5–9 | 0.93 (0.76 to 1.12) | 0.442 | fp1(◯–2–3.88) | 0.98 (0.94 to 1.02) | 0.374 | |||

9+ | 1.01 (0.76 to 1.35) | 0.919 | fp2(◯2*ln(x)+2.63) | 0.99 (0.97 to 1.01) | 0.381 | |||

Interaction§ | 0.455 | |||||||

Students 16–19 years | ||||||||

For each additional missing tooth | 1.02 (0.99 to 1.07) | 0.227 | 0–4 | 1.00 | 0.656‡ | |||

5–9 | 0.96 (0.70 to 1.30) | 0.776 | fp1(◯–2–4.16) | 0.94 (0.87 to 1.02) | 0.163 | |||

9+ | 1.23 (0.76 to 2.00) | 0.400 | fp2(◯2*ln(x)+2.97) | 0.97 (0.94 to 1.01) | 0.167 | |||

Students 20–23 years | ||||||||

For each additional missing tooth | 0.99 (0.95 to 1.03) | 0.702 | 0–4 | 1.00 | 0.515‡ | |||

5–9 | 0.98 (0.71 to 1.34) | 0.885 | fp1(◯2–0.24) | 0.8 (0.45 to 1.44) | 0.461 | |||

9+ | 0.80 (0.45 to 1.41) | 0.438 | fp2(◯3–0.12) | 1.08 (0.88 to 1.32) | 0.462 | |||

Students 24–30 years | ||||||||

For each additional missing tooth | 0.99 (0.95 to 1.02) | 0.502 | 0–4 | 1.00 | 0.497‡ | |||

5–9 | 0.77 (0.52 to 1.15) | 0.197 | fp1(◯3–0.24) | 0.86 (0.66 to 1.11) | 0.253 | |||

9+ | 0.93 (0.59 to 1.48) | 0.752 | fp2(◯3*ln(x)+0.11) | 1.14 (0.89 to 1.46) | 0.288 |