Table 3 Patient demographic and clinical characteristics according to study drug
VariablesEarly abciximabLate abciximabEarly tirofibanLate tirofibanEarly eptifibatideLate eptifibatide
(n  =  302)(n  =  310)(n  =  311)(n  =  321)(n  =  227)(n  =  191)
Age, years
    Median616262625859
    25–75th percentiles52–6952–7254–7052–7050–7051–68
Sex, n (%)228/302 (75.5%)239/310 (77.1%)249/311 (80.1%)259/321 (80.7%)165/227 (72.7%)143/191 (74.9%)
Hypertension, n (%)143/301 (47.5%)143/310 (46.1%)97/311 (31.2%)110/321 (34.3%)113/226 (50.0%)94/191 (49.2%)
Diabetes, n (%)61/302 (20.2%)69/310 (22.3%)37/311 (11.9%)42/321 (13.1%)35/227 (15.4%)37/191 (19.4%)
Previous MI, n (%)14/301 (4.7%)26/310 (8.4%)21/310 (6.8%)31/321 (9.7%)32/227 (14.1%)23/191 (12.0%)
Previous revascularisation, n (%)9/254 (3.5%)13/258 (5.0%)22/311 (7.1%)22/321 (6.9%)30/227 (13.2%)24/191 (12.6%)
Smoking, n (%)151/302 (50.0%)146/310 (47.1%)176/311 (56.6%)196/321 (61.1%)113/227 (49.8%)77/191 (40.3%)
Hypercholesterolemia, n (%)135/302 (44.7%)142/309 (46.0%)78/311 (25.1%)90/321 (28.0%)85/227 (37.4%)77/190 (40.5%)
Killip class III/IV, n (%)15/302 (4.9%)14/310 (4.4%)3/251 (1.2%)4/256 (1.6%)15/169 (9.2%)15/139 (10.8%)
Anterior MI, n (%)153/302 (50.7%)157/310 (50.6%)127/311 (40.8%)138/321 (43.0%)81/218 (37.2%)74/188 (39.4%)
Symptom onset to Gp IIb–IIIa inhibitor time, minutes*
    Median13020364191150199
    25–75th percentiles800–203145–30050–85145–26495–257138–267
Ischaemia time, minutes
    Median194208193198191210
    25–75th percentiles145–271150–300150–249150–270138–295147–303
Infarct-related artery
    LAD, n (%)151 (50%)153 (49.4%)123 (39.5%)134 (41.7%)77 (33.9%)74 (38.7%)
    CX, n (%)34 (11.3%)30(9.7%)51 (16.4%)41 (12.8%)39 (17.2%)29 (15.2%)
    RCA, n (%)113 (37.4%)122 (39.4%)123 (39.5%)131 (40.8%)103 (45.3%)83 (43.5%)
    GRAFT, n (%)06 (0.7%)2 (0.6%)4 (1.2%)4 (1.8%)2 (1.0%)
    LM, n (%)03 (1.0%)4 (1.3%)1 (0.3%)01 (0.5%)
Multivessel disease, n (%)120/254 (47.2%)142/258 (55.0%)150/282 (53.2%)147/289 (50.9%)167/221 (75.6%)144/190 (75.8%)
Follow-up
    Median1801803573563030
    25–75th percentiles30–36030–360346–360342–36030–3030–30
  • All p values are not significant except for the time from symptom onset to administration of Gp IIb–IIIa inhibitors* (p<0.001).

  • CX, circumflex artery; Gp, glycoprotein; LAD, left descending coronary artery; LM, left main artery; MI, myocardial infarction; RCA, right coronary artery.