| Parameters | All patients (n = 39) | Responders (n = 21) | Non-responders (n = 18) | |||
| Baseline | Three months | Baseline | Three months | Baseline | Three months | |
| Global cardiac function | ||||||
| LV end-diastolic volume (cm3) | 179 (64) | 162 (70)* | 169 (44) | 138 (42)* | 190 (82) | 190 (86) |
| LV end-systolic volume (cm3) | 131 (56) | 109 (60)* | 121 (37) | 85 (34)* | 143 (71) | 138 (70)† |
| LV ejection fraction (%) | 28.1 (6.7) | 35.0 (9.4)* | 29.5 (6.0) | 40.1 (7.7)* | 26.4 (7.2) | 29.0 (7.5)‡ |
| Mitral regurgitation (% LA area) | 36 (22) | 25 (19)‡ | 33 (19) | 19 (17)* | 40 (26) | 32 (20) |
| LV geometry | ||||||
| End-diastolic length (cm) | 8.87 (0.94) | 8.63 (1.02)† | 8.86 (0.78) | 8.56 (0.89)† | 8.90 (1.13) | 8.75 (1.18) |
| End-systolic length (cm) | 8.12 (1.10) | 7.86 (1.06) | 8.11 (0.77) | 7.64 (0.97)‡ | 8.12 (1.44) | 8.12 (1.15) |
| End-diastolic mid-cavity width (cm) | 5.61 (0.94) | 5.17 (0.91)‡ | 5.38 (0.72) | 4.87 (0.58)* | 5.88 (1.12) | 5.54 (1.11) |
| End-systolic mid-cavity width (cm) | 4.76 (0.84) | 4.37 (0.89)* | 4.55 (0.67) | 4.04 (0.67)‡ | 5.02 (0.97) | 4.82 (0.96) |
| End-diastolic sphericity index | 1.61 (0.22) | 1.67 (0.21)† | 1.68 (0.22) | 1.77 (0.21)‡ | 1.54 (0.22) | 1.60 (0.19) |
| End-systolic sphericity index | 1.74 (0.28) | 1.84 (0.29† | 1.81 (0.27) | 1.93 (0.30)† | 1.64 (0.27)§ | 1.71 (0.23) |
| Myocardial function | ||||||
| Mean ϵ-circum (%) | −7.1 (2.6) | −8.5 (3.2)‡ | −7.9 (2.4) | −10.0 (2.9)‡ | −6.1 (2.6)§ | −6.8 (2.6) |
| Mean ϵ-radial (%) | 10.6 (6.3) | 14.2 (9.3)† | 11.6 (6.2) | 18.8 (9.1)† | 9.4 (6.4) | 8.7 (5.9) |
| Tor, degree | 6.8 (4.2) | 5.0 (4.8)† | 6.8 (4.5) | 5.6 (5.6) | 6.9 (4.1) | 4.2 (3.7)† |
| Mean ϵ-long (%) | −7.6 (3.3) | −7.7 (3.4) | −8.0 (2.9) | −9.0 (3.5) | −7.1 (3.8) | −6.2 (2.7) |
| ϵ-circum-(No) | 3.1 (1.7) | 2.2 (1.6)† | 2.6 (1.6) | 1.7 (1.6)† | 3.8 (1.8)§ | 2.7 (1.6) |
| ϵ-radial-(No) | 3.7 (2.7) | 2.7 (2.4)† | 3.4 (2.4) | 1.7 (2.1)† | 4.3 (3.0) | 3.9 (2.2) |
| Torsion-(No) | 2.4 (2.3) | 3.4 (3.0) | 2.9 (2.3) | 3.1 (3.3) | 1.9 (2.3) | 3.8 (2.7)† |
| ϵ-long-(No) | 2.0 (1.8) | 1.9 (2.2) | 1.9 (1.7) | 1.5 (2.2) | 2.1 (1.9) | 2.5 (1.2) |
*p<0.001, †p<0.05, ‡p⩽0.005 vs baseline; §p<0.05 vs responders at baseline.
ϵ-circum, circumferential strain; ϵ-radial, radial strain; Tor, torsion; ϵ-long, longitudinal strain; Rot, rotation; ϵ-circum-(No), number of paradoxical tracing for circumferential strain; ϵ-radial-(No), number of paradoxical tracing for radial strain; Torsion-(No), number of paradoxical tracing for torsion; ϵ-long-(No), number of paradoxical tracing for longitudinal strain.