Table 1 Demographic and clinical characteristics of patients in the derivation and validation cohorts
VariableDerivation cohort (n = 260)Validation cohort (n = 256)p Value
Age, mean (SD)63 (21)63 (22)
Male156 (60)121 (47)0.005
Structural heart disease*77 (30)73 (29)
Abnormal ECG*111 (43)89 (35)
No of syncopal episodes, mean (SD)2 (5)3 (5)
Injures related to syncope75 (29)60 (23)
History of presyncope51 (20)62 (24)
Final diagnosis
    Cardiac syncope44 (17)35 (14)
        Bradyarrhythmic21 (8)17 (7)
        Tachyarrhythmic9 (3)9 (4)
        Mechanical14 (5)9 (4)
    Neurally mediated165 (63)179 (70)
        Vasovagal85 (33)110 (43)0.02
        Carotid sinus syncope13 (5)10 (4)
        Situational46 (18)42 (16)
        Single/rare syncope, no heart disease21 (8)17 (7)
    Orthostatic hypotension27 (10)25 (10)
    Non syncopal attacks18 (7)10 (4)
    Unexplained5 (2)8 (3)
  • Results are shown as no (%) unless stated otherwise.

  • *As defined in the method section.