Table 4 Factors associated with ischaemic ECG changes* in men and women
VariablesMenWomen
AllWith ischaemiaUnadjusted odds ratio (95% CI)Adjusted odds ratio (95% CI)AllWith ischaemiaUnadjusted odds ratio (95% CI)Adjusted odds ratio (95% CI)
Subjects, No (%)1372251 (18.3)101163 (6.2)
Age (years), mean (SD)51.3 (10.2)55.2 (11.6)1.02 (1.01 to 1.04)1.02 (1.01 to 1.03)50.953.3 (11.6)1.02 (1.01 to 1.03)1.01 (1.00 to 1.03)
Past smoker†, No (%)264 (19.2)67.0 (26.7)1.01 (0.77 to 1.30)1.36 (0.97 to 1.89)12 (0.84)06 (1.2)1.95 (0.51 to 7.44)NS§
Waist to hip ratio, mean (SD)0.94 (0.08)0.96 (0.07)0.95 (0.85 to 1.05)NS0.86 (0.07)0.87 (0.07)1.28 (1.11 to 1.47)1.19 (1.02 to 1.38)
Body mass index, mean (SD)24.3 (4.7)24.9 (4.6)1.03 (1.01 to 1.04)NS26.5 (5.7)26.8 (5.5)1.01 (1.00 to 1.01)NS
Hypertriglyceridaemia, No (%)546 (39.8)114 (45.4)1.22 1.02 to 1.47)NS562 (39.1)204 (41.8)1.18 (0.91 to 1.54)NS
Low LDL, No (%)491 (35.8)76 (30.3)0.82 (0.71 to 0.94)NS491 (34.2)158 (32.4)0.88 (0.75 to 1.03)NS
Low HDL, No (%)963 (70.2)168 (66.9)1.06 (0.90 to 1.24)NS1127 (78.5)388 (79.5)1.09 (0.83 to 1.44)NS
Physical activity431 (31.4)65 (25.9)0.71 (0.59 to 0.86)NS255 (17.8)83 (17.0)0.92 (0.67 to 1.26)NS
Hypertension443 (32.3)138 (54.9)2.71 (2.35 to 3.12)2.81 (2.12 to 3.72)722 (50.3)301 (61.7)2.01 (1.53 to 2.64)1.82 (1.36 to 2.44)
Diabetes238 (17.5)61 (24.3)1.38 (1.15 to 1.65)1.50 (1.11 to 2.02)314 (21.8)113 (23.1)1.12 (0.87 to 1.43)NS
‡Metabolic syndrome630 (45.9)142 (56.6)1.74 (1.49 to 2.01)Not applicable822 (57.2)314 (64.3)1.56 (1.26 to 1.93)Not applicable
  • *Major ECG abnormalities defined as the following codes on ECG: Minnesota codes 4-1 or 4-2 or 5-1 or 5-2 or 6-1 or 6-2 or 7-1 or 7-2 or 8-1 or 8-3.

  • †Past smokers defined as those who smoked ⩾100 cigarettes in their lifetime.

  • ‡Metabolic syndrome defined as the concomitant presence of at least three of the following: hypertension, high triglycerides (>1.70 mmol/l); or low HDL cholesterol (<1.04 mmol/l in men or <1.30 mmol/l in women), impaired glucose tolerance (fasting glucose ⩾6.1 mmol/l), or central obesity.

  • §NS, not significant in the multivariable model and therefore not retained in the final model.

  • HDL, high-density lipoprotein; LDL, low-density lipoprotein.